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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CCT2  -  chaperonin containing TCP1, subunit 2 (beta)

Homo sapiens

Synonyms: 99D8.1, CCT-beta, CCTB, Cctb, HEL-S-100n, ...
 
 
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Disease relevance of CCT2

  • The performance of 100 9-16-year-old children with traumatic head injury (THI) on the Children's Category Test (CCT-2; Boll, 1993) was examined to determine the underlying factor structure [1].
 

High impact information on CCT2

  • Several interesting genes with a potential role in the regulation of cell cycle progression were also identified to increase in expression, including Pescadillo and chaperonin CCT2 [2].
  • The latent structure of the Children's Category Test (CCT; Boll, 1993) was evaluated in the standardization sample, with separate principal factor analyses for the younger subgroup (ages 5-8 years; CCT-1) and the older subgroup (ages 9-16 years; CCT-2) [3].
  • Boanmycin (bleomycin A6, BM), an antitumor antibiotic, was conjugated to monoclonal antibodies including R19, H111 and CCT2 [4].
 

Analytical, diagnostic and therapeutic context of CCT2

  • Northern blotting revealed no effects of the cytokine on steady-state levels of CCTalpha mRNA, and CCTbeta mRNA was not detected [5].

References

  1. Latent structure of the Children's Category Test after pediatric traumatic head injury. Nesbit-Greene, K., Donders, J. Journal of clinical and experimental neuropsychology : official journal of the International Neuropsychological Society. (2002) [Pubmed]
  2. Effects of estrogen on global gene expression: identification of novel targets of estrogen action. Charpentier, A.H., Bednarek, A.K., Daniel, R.L., Hawkins, K.A., Laflin, K.J., Gaddis, S., MacLeod, M.C., Aldaz, C.M. Cancer Res. (2000) [Pubmed]
  3. Latent structure of the Children's Category Test at two age levels in the standardization sample. Donders, J. Journal of clinical and experimental neuropsychology : official journal of the International Neuropsychological Society. (1999) [Pubmed]
  4. Antitumor activity of immunoconjugates composed of boanmycin and monoclonal antibody. Zhen, Y., Peng, Z., Deng, Y., Xu, H., Chen, Y., Tian, P., Li, D., Jiang, M. Chin. Med. Sci. J. (1994) [Pubmed]
  5. Tumor necrosis factor-alpha inhibits expression of CTP:phosphocholine cytidylyltransferase. Mallampalli, R.K., Ryan, A.J., Salome, R.G., Jackowski, S. J. Biol. Chem. (2000) [Pubmed]
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