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Rrn3  -  RRN3 RNA polymerase I transcription factor...

Mus musculus

Synonyms: AL023001, E130302O19Rik, R75565, RNA polymerase I-specific transcription initiation factor RRN3, TIF-1A, ...
 
 
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Disease relevance of Rrn3

 

High impact information on Rrn3

  • These results suggest that the phosphorylation state of Rrn3 regulates rDNA transcription by determining the steady-state concentration of the Rrn3.RNA polymerase I complex within the nucleolus [1].
  • The mouse homologue of yeast Rrn3, a polymerase-associated transcription initiation factor, can complement extracts from cycloheximide-treated mammalian cells [1].
  • Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis [1].

References

  1. Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis. Cavanaugh, A.H., Hirschler-Laszkiewicz, I., Hu, Q., Dundr, M., Smink, T., Misteli, T., Rothblum, L.I. J. Biol. Chem. (2002) [Pubmed]
 
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