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Gene Review

NPRL2  -  nitrogen permease regulator-like 2 (S....

Homo sapiens

Synonyms: G21 protein, Gene 21 protein, NPR2, NPR2-like protein, NPR2L, ...
 
 
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Disease relevance of TUSC4

  • Initial analysis identified the NPRL2/G21 gene located in 3p21.3C, the lung cancer region, as a strong candidate tumor suppressor gene [1].
  • We report inactivating mutations in a variety of tumors and cancer cell lines, growth suppression of tumor cells with tet-controlled NPRL2/G21 transgenes on plastic Petri dishes, and suppression of tumor formation in SCID mice [1].
  • Intratumoral injection of Ad-101F6, Ad-FUS1, Ad-NPRL2, and Ad-HYAL2 vectors or systemic administration of protamine-complexed vectors significantly suppressed growth of H1299 and A549 tumor xenografts and inhibited A549 experimental lung metastases in nu/nu mice [2].
  • Localization of varicella-zoster virus gene 21 protein in virus-infected cells in culture [3].
 

High impact information on TUSC4

  • Functional characterization of the candidate tumor suppressor gene NPRL2/G21 located in 3p21.3C [1].
  • Screening of 7 renal, 5 lung, and 7 cervical carcinoma cell lines showed homozygous deletions in the 3' end of NPRL2 in 2 renal, 3 lung, and 1 cervical (HeLa) cell line [1].
  • The yeast NPR2 was shown to be a target of cisplatin, suggesting that the human NPRL2/G21 may play a similar role [1].
  • We speculate that the NPRL2/G21 nuclear protein may be involved in mismatch repair, cell cycle checkpoint signaling, and activation of apoptotic pathway(s) [1].
  • At least two homozygous deletions of NPRL2/G21 were detected in 6 tumor biopsies from various locations and with microsatellite instability [1].
 

Biological context of TUSC4

 

Anatomical context of TUSC4

References

  1. Functional characterization of the candidate tumor suppressor gene NPRL2/G21 located in 3p21.3C. Li, J., Wang, F., Haraldson, K., Protopopov, A., Duh, F.M., Geil, L., Kuzmin, I., Minna, J.D., Stanbridge, E., Braga, E., Kashuba, V.I., Klein, G., Lerman, M.I., Zabarovsky, E.R. Cancer Res. (2004) [Pubmed]
  2. Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo. Ji, L., Nishizaki, M., Gao, B., Burbee, D., Kondo, M., Kamibayashi, C., Xu, K., Yen, N., Atkinson, E.N., Fang, B., Lerman, M.I., Roth, J.A., Minna, J.D. Cancer Res. (2002) [Pubmed]
  3. Localization of varicella-zoster virus gene 21 protein in virus-infected cells in culture. Mahalingam, R., Lasher, R., Wellish, M., Cohrs, R.J., Gilden, D.H. J. Virol. (1998) [Pubmed]
  4. Transcript mapping and transregulatory behavior of varicella-zoster virus gene 21, a latency-associated gene. Xia, D., Straus, S.E. Virology (1999) [Pubmed]
 
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