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Gene Review

GFND  -  glomerulopathy with fibronectin deposits

Homo sapiens

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Disease relevance of GFND

 

High impact information on GFND

  • This interval contains a cluster of genes for "regulators of complement activation" (RCA), which represent strong candidates for GFND [2].
  • We have recently localized a gene locus for GFND to human chromosome 1q32 by total genome linkage analysis in a large kindred, within a 4.1-cM critical interval between markers D1S2872 and D1S2891 [2].
 

Analytical, diagnostic and therapeutic context of GFND

  • Molecular cloning of the critical region for glomerulopathy with fibronectin deposits (GFND) and evaluation of candidate genes [2].

References

  1. The gene for human fibronectin glomerulopathy maps to 1q32, in the region of the regulation of complement activation gene cluster. Vollmer, M., Jung, M., Rüschendorf, F., Ruf, R., Wienker, T., Reis, A., Krapf, R., Hildebrandt, F. Am. J. Hum. Genet. (1998) [Pubmed]
  2. Molecular cloning of the critical region for glomerulopathy with fibronectin deposits (GFND) and evaluation of candidate genes. Vollmer, M., Kremer, M., Ruf, R., Miot, S., Nothwang, H.G., Wirth, J., Otto, E., Krapf, R., Hildebrandt, F. Genomics (2000) [Pubmed]
 
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