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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Ssr1  -  signal sequence receptor, alpha

Mus musculus

Synonyms: 2510001K09Rik, 6330400D04, AI159733, AI452176, SSR, ...
 
 
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Disease relevance of Ssr1

  • In this study, we documented the effects of different peripheral benzodiazepine receptor (PBR) ligands: PK 11195, Ro5-4864 and the newly described SSR 180575 on the development of pulmonary inflammation in vivo [1].
 

High impact information on Ssr1

  • We have determined the order of a number of SSR and SSC polymorphic markers that map to distal mouse Chromosome (Chr) 4 and have used analysis of these markers in backcrosses designed to test the localization of the curly-tail (ct) mutation [2].
 

Analytical, diagnostic and therapeutic context of Ssr1

  • The unique sequences flanking the repeats are used to design PCR primers to amplify the repeat and gene-associated SSR length differences that are informative for linkage analysis used in canine pedigrees to study linkage between loci or with diseases [3].

References

  1. Ligands of the peripheral benzodiazepine receptor have therapeutic effects in pneumopathies in vivo. Bribes, E., Bourrie, B., Casellas, P. Immunol. Lett. (2003) [Pubmed]
  2. Haplotype analysis of intra-specific backcross curly-tail mice confirms the localization of ct to chromosome 4. Beier, D.R., Dushkin, H., Telle, T. Mamm. Genome (1995) [Pubmed]
  3. A comparative approach to physical and linkage mapping of genes on canine chromosomes using gene-associated simple sequence repeat polymorphisms illustrated by studies of dog chromosome 9. Werner, P., Raducha, M.G., Prociuk, U., Henthorn, P.S., Patterson, D.F. J. Hered. (1999) [Pubmed]
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