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Gene Review:

Lgals2 - lectin, galactose-binding, soluble 2

Mus musculus

Synonyms: 2200008F12Rik, AI324147, Gal-2, Galectin-2

Nio, J. et al., Naoum, J.J. et al.

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Disease relevance of Lgals2

Several genetic and clinical studies implicate LTalpha, and its binding and regulatory partner galectin-2, as a risk factor in the pathogenesis of cardiovascular diseases including miocardial infarction, aortic aneurysm, and cerebral infarction [1].

High impact information on Lgals2

Galectin-2 was intensely expressed from crypts to the base of villi, whereas transcripts of galectin-3 gathered at villous tips [2].
The small intestine exhibited intense, maturation-associated expressions of galectin-2, -3, and -4/6 mRNAs [2].
In the glandular stomach, galectin-2 and -4/6 were predominantly expressed from gastric pits to neck of gastric glands, where mucous cells were the main cellular sources [2].

References

Lymphotoxin-alpha and cardiovascular disease: clinical association and pathogenic mechanisms. Naoum, J.J., Chai, H., Lin, P.H., Lumsden, A.B., Yao, Q., Chen, C. Med. Sci. Monit. (2006) [Pubmed]
Differential cellular expression of galectin family mRNAs in the epithelial cells of the mouse digestive tract. Nio, J., Kon, Y., Iwanaga, T. J. Histochem. Cytochem. (2005) [Pubmed]

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