The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Jmjd6  -  jumonji domain containing 6

Mus musculus

Synonyms: 5730436I23Rik, Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6, D11Ertd195e, Histone arginine demethylase JMJD6, JmjC domain-containing protein 6, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Jmjd6

 

High impact information on Jmjd6

 

Biological context of Jmjd6

  • CONCLUSION: Ptdsr is essential for the development and differentiation of multiple organs during embryogenesis but not for apoptotic cell removal [1].
  • Activation of protein kinase C beta II by the stereo-specific phosphatidylserine receptor is required for phagocytosis of apoptotic thymocytes by resident murine tissue macrophages [5].
  • These data demonstrate a critical role for PSR in early stages of mammalian organogenesis and suggest that this receptor may be involved in respiratory distress syndromes and congenital brain malformations [6].
  • Expression of phosphatidylserine receptor and down-regulation of pro-inflammatory molecule production by its natural ligand in rat microglial cultures [7].
  • 4. During normal respiration, PSR firing rate increased with tidal volume, but reached significantly higher values in OF1 than C3H mice [8].
 

Anatomical context of Jmjd6

  • Moreover, Ptdsr is not required for apoptotic cell clearance by macrophages but seems to be necessary for the regulation of macrophage cytokine responses [1].
  • In addition, PSR(-/-) embryos exhibited thymus atrophy owing to a developmental defect of T-lymphoid cells [3].
  • Semi-quantitative RT-PCR analysis revealed that PtdSerR mRNA was detectable in unstimulated cultures and enhanced in LPS activated microglia [7].
 

Associations of Jmjd6 with chemical compounds

  • A comprehensive investigation of apoptotic cell clearance in vivo and in vitro demonstrated that engulfment of apoptotic cells was normal in Ptdsr knockout mice, but Ptdsr-deficient macrophages were impaired in pro- and anti-inflammatory cytokine signaling after stimulation with apoptotic cells or with lipopolysaccharide [1].
  • Components with short mean durations declined and components with long mean durations increased in relative frequency at higher GABA concentration indicating at least two binding sites of GABA per 28 and 12 pS receptor [9].
  • These results suggest endocytosis of archaeosomes rich in surface-exposed phosphoserine head groups via a phosphatidylserine receptor, and energy-independent surface adsorption of certain other archaeosome composition classes [10].
 

Other interactions of Jmjd6

  • RESULTS: Ablation of Ptdsr function in mice causes perinatal lethality, growth retardation and a delay in terminal differentiation of the kidney, intestine, liver and lungs during embryogenesis [1].
  • Endogenously produced TGF-beta is suggested to play an autocrine or paracrine priming role in the induction of the PS receptor [11].
 

Analytical, diagnostic and therapeutic context of Jmjd6

References

  1. The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal. Böse, J., Gruber, A.D., Helming, L., Schiebe, S., Wegener, I., Hafner, M., Beales, M., Köntgen, F., Lengeling, A. J. Biol. (2004) [Pubmed]
  2. Hide and seek: the secret identity of the phosphatidylserine receptor. Williamson, P., Schlegel, R.A. J. Biol. (2004) [Pubmed]
  3. Defective fetal liver erythropoiesis and T lymphopoiesis in mice lacking the phosphatidylserine receptor. Kunisaki, Y., Masuko, S., Noda, M., Inayoshi, A., Sanui, T., Harada, M., Sasazuki, T., Fukui, Y. Blood (2004) [Pubmed]
  4. Phosphatidylserine receptor-mediated recognition of archaeosome adjuvant promotes endocytosis and MHC class I cross-presentation of the entrapped antigen by phagosome-to-cytosol transport and classical processing. Gurnani, K., Kennedy, J., Sad, S., Sprott, G.D., Krishnan, L. J. Immunol. (2004) [Pubmed]
  5. Activation of protein kinase C beta II by the stereo-specific phosphatidylserine receptor is required for phagocytosis of apoptotic thymocytes by resident murine tissue macrophages. Todt, J.C., Hu, B., Punturieri, A., Sonstein, J., Polak, T., Curtis, J.L. J. Biol. Chem. (2002) [Pubmed]
  6. Phosphatidylserine receptor is required for clearance of apoptotic cells. Li, M.O., Sarkisian, M.R., Mehal, W.Z., Rakic, P., Flavell, R.A. Science (2003) [Pubmed]
  7. Expression of phosphatidylserine receptor and down-regulation of pro-inflammatory molecule production by its natural ligand in rat microglial cultures. De, S.R., Ajmone-Cat, M.A., Nicolini, A., Minghetti, L. J. Neuropathol. Exp. Neurol. (2002) [Pubmed]
  8. Pulmonary stretch receptor discharges and vagal regulation of respiration differ between two mouse strains. Burnet, H., Hilaire, G. J. Physiol. (Lond.) (1999) [Pubmed]
  9. Single-channel properties of neuronal GABAA receptors from mice lacking the 2 subunit. Lorez, M., Benke, D., Luscher, B., Mohler, H., Benson, J.A. J. Physiol. (Lond.) (2000) [Pubmed]
  10. Archaeosomes varying in lipid composition differ in receptor-mediated endocytosis and differentially adjuvant immune responses to entrapped antigen. Sprott, G.D., Sad, S., Fleming, L.P., Dicaire, C.J., Patel, G.B., Krishnan, L. Archaea (2003) [Pubmed]
  11. Particle digestibility is required for induction of the phosphatidylserine recognition mechanism used by murine macrophages to phagocytose apoptotic cells. Fadok, V.A., Laszlo, D.J., Noble, P.W., Weinstein, L., Riches, D.W., Henson, P.M. J. Immunol. (1993) [Pubmed]
  12. Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique. Schneider, J.E., Böse, J., Bamforth, S.D., Gruber, A.D., Broadbent, C., Clarke, K., Neubauer, S., Lengeling, A., Bhattacharya, S. BMC Dev. Biol. (2004) [Pubmed]
 
WikiGenes - Universities