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Gene Review:

Slc22a7 - solute carrier family 22 (organic anion...

Mus musculus

Synonyms: NLT, OAT2, Oat2, Organic anion transporter 2, Solute carrier family 22 member 7, ...

Kobayashi, Y. et al., Zhen, S. et al., Lopez-Nieto, C.E. et al., Burckhardt, B.C. et al., Joffroy, S. et al.

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Disease relevance of Slc22a7

The NLT and Gn11 cells, derived from a same brain tumor in a transgenic mouse, display neuronal morphology and neuron-specific markers [1].

High impact information on Slc22a7

Nevertheless, the overall homology of NKT to two recently cloned organic ion transport proteins (NLT and OCT-1) is significantly greater; together these three gene products may represent a new subgroup of transporters [2].
In this study, two immortalized GnRH-expressing cell lines (Gn11 and NLT) were characterized [1].
Human, rat and mouse OAT2 transported selected anti-inflammatory and antiviral drugs, methotrexate, ochratoxin A, and, with high affinities, prostaglandins E(2) and F(2alpha) [3].
The gene coding for mOAT2, Slc22a7, is found on chromosome 17C [4].
In addition, we found that there exists a sex- and species-related differential gene expression of the OAT2 isoform [4].

Biological context of Slc22a7

We isolated cDNA encoding a multispecific organic anion transporter 2 (OAT2) from the mouse kidney cDNA library [4].

Anatomical context of Slc22a7

Thus, when the transition from myoblasts to myotubes was slow, and the absolute level of fusion was reduced, as in the NLT cell line, the level of m-calpain was stable [5].

References

An alternative gonadotropin-releasing hormone (GnRH) RNA splicing product found in cultured GnRH neurons and mouse hypothalamus. Zhen, S., Dunn, I.C., Wray, S., Liu, Y., Chappell, P.E., Levine, J.E., Radovick, S. J. Biol. Chem. (1997) [Pubmed]
Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney. Lopez-Nieto, C.E., You, G., Bush, K.T., Barros, E.J., Beier, D.R., Nigam, S.K. J. Biol. Chem. (1997) [Pubmed]
Transport of organic anions across the basolateral membrane of proximal tubule cells. Burckhardt, B.C., Burckhardt, G. Rev. Physiol. Biochem. Pharmacol. (2003) [Pubmed]
Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice. Kobayashi, Y., Ohshiro, N., Shibusawa, A., Sasaki, T., Tokuyama, S., Sekine, T., Endou, H., Yamamoto, T. Mol. Pharmacol. (2002) [Pubmed]
M-calpain levels increase during fusion of myoblasts in the mutant muscular dysgenesis (mdg) mouse. Joffroy, S., Dourdin, N., Delage, J.P., Cottin, P., Koenig, J., Brustis, J.J. Int. J. Dev. Biol. (2000) [Pubmed]

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