Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Bdv1 - BALB/c defective provirus 1

Mus musculus

Synonyms: Bdv-1

Stoye, J.P. et al., Stoye, J.P. et al.

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Disease relevance of Bdv1

We identify a novel locus, Bdv-1, which controls the expression of a reverse transcriptase-positive, defective retrovirus in BALB/cTif lymphocytes [1].
Mitogen treatment of murine (BALB/c) B-cells induces two different endogenous retroviruses involving two unlinked, presumably proviral, loci Bxv-1 and Bdv-1 [2].

High impact information on Bdv1

Bxv-1 is induced mainly by BrdU and only marginally by mitogen; in contrast, Bdv-1 is induced by mitogen and BrdU has little effect [1].

Biological context of Bdv1

The data imply that Bxv-1- and Bdv-1-dependent virus production require DNA synthesis and cell proliferation and, at least for Bxv-1, B-cell differentiation [2].

References

Endogenous retrovirus expression in stimulated murine lymphocytes. Identification of a new locus controlling mitogen induction of a defective virus. Stoye, J.P., Moroni, C. J. Exp. Med. (1983) [Pubmed]
Proliferation and differentiation requirements for the induction of two retroviral loci during B-cell activation. Stoye, J.P., Moroni, C. J. Gen. Virol. (1985) [Pubmed]

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