The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

Xmmv63  -  xenotropic-MCF leukemia virus 63

Mus musculus

Synonyms: Xmmv-63, Xp-22
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Xmmv63

  • The breakpoints on the X chromosome in these five translocations are in Xp22 [1].
  • Microphthalmia with linear skin defects (MLS) is an X-linked dominant, male-lethal syndrome characterized by microphthalmia, aplastic skin and agenesis of the corpus callosum, and is caused by the deletion of a 500 kb critical region in Xp22 [2].
  • The proximal half of the AZFa interval is occupied by pseudogene sequences with homology to Xp22 [3].
  • SCML2 maps very close to the recently identified SCML1, revealing the presence of a new gene cluster in Xp22 [4].
  • The gene maps close to DXS7101 31.9 cM from the short arm telomere of the X-chromosome at Xp22 [5].

Biological context of Xmmv63

  • Our in silico search for candidate genes noted that annotation of a human Xp22 PAC (RPCI1-258N20) sequence (GenBank Accession No. AC002504) identified putative exons consistent with an Arx homologue in Xp22 [6].

Analytical, diagnostic and therapeutic context of Xmmv63

  • Southern blot analysis of DNA from a variety of mammalian species shows restricted conservation of human pseudoautosomal genes, a trend that also applies to the two cloned mouse homologs of these genes and to neighboring human genes in distal Xp22 [7].


  1. Fine mapping of the distal short arm of the human X chromosome using X/Y translocations. Geller, R.L., Shapiro, L.J., Mohandas, T.K. Am. J. Hum. Genet. (1986) [Pubmed]
  2. Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA. Prakash, S.K., Paylor, R., Jenna, S., Lamarche-Vane, N., Armstrong, D.L., Xu, B., Mancini, M.A., Zoghbi, H.Y. Hum. Mol. Genet. (2000) [Pubmed]
  3. The critical region of overlap defining the AZFa male infertility interval of proximal Yq contains three transcribed sequences. Sargent, C.A., Boucher, C.A., Kirsch, S., Brown, G., Weiss, B., Trundley, A., Burgoyne, P., Saut, N., Durand, C., Levy, N., Terriou, P., Hargreave, T., Cooke, H., Mitchell, M., Rappold, G.A., Affara, N.A. J. Med. Genet. (1999) [Pubmed]
  4. Identification of SCML2, a second human gene homologous to the Drosophila sex comb on midleg (Scm): A new gene cluster on Xp22. Montini, E., Buchner, G., Spalluto, C., Andolfi, G., Caruso, A., den Dunnen, J.T., Trump, D., Rocchi, M., Ballabio, A., Franco, B. Genomics (1999) [Pubmed]
  5. Identification, mapping, and genomic structure of a novel X-chromosomal human gene (SMPX) encoding a small muscular protein. Patzak, D., Zhuchenko, O., Lee, C.C., Wehnert, M. Hum. Genet. (1999) [Pubmed]
  6. Human ARX gene: genomic characterization and expression. Ohira, R., Zhang, Y.H., Guo, W., Dipple, K., Shih, S.L., Doerr, J., Huang, B.L., Fu, L.J., Abu-Khalil, A., Geschwind, D., McCabe, E.R. Mol. Genet. Metab. (2002) [Pubmed]
  7. Rapid evolution of human pseudoautosomal genes and their mouse homologs. Ellison, J.W., Li, X., Francke, U., Shapiro, L.J. Mamm. Genome (1996) [Pubmed]
WikiGenes - Universities