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Gene Review:

Oxsr1 - oxidative-stress responsive 1

Mus musculus

Synonyms: 2210022N24Rik, 2810422B09Rik, AI462649, AW209236, Osr1, ...

Akhand, A.A. et al., Zhang, Z. et al., Ricci, S. et al., Helenius, M. et al., Tang, Y. et al., et al.

Ricci, Janulczyk, Björck,

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Disease relevance of Oxsr1

Escherichia coli and Bacillus subtilis aconitases can act as iron and oxidative stress-responsive post-transcriptional regulators [1].
Expression of oxidative stress-responsive genes and cytokine genes during caerulein-induced acute pancreatitis [2].

High impact information on Oxsr1

The mutant showed hyperresistance to hydrogen peroxide, and this response was induced in wild-type cells by growth in aerobiosis, suggesting that PerR acts as an oxidative stress-responsive repressor [3].
Aging-induced up-regulation of nuclear binding activities of oxidative stress responsive NF-kB transcription factor in mouse cardiac muscle [4].
By use of a specifically sulfhydryl group-reactive chemical, 1,4-butanediyl-bismethanethiosulfonate (BMTS), we studied the localization of oxidative stress-responsive target cysteines for activation of a receptor-type protein tyrosine kinase, c-RET [5].
Urea treatment (100-300 mM) increased expression of the oxidative stress-responsive transcription factor, Gadd153/CHOP, at the mRNA and protein levels (at >/=4 h) in renal medullary mIMCD3 cells in culture, whereas other solutes did not [6].

References

Post-transcriptional regulation of bacterial motility by aconitase proteins. Tang, Y., Guest, J.R., Artymiuk, P.J., Read, R.C., Green, J. Mol. Microbiol. (2004) [Pubmed]
Expression of oxidative stress-responsive genes and cytokine genes during caerulein-induced acute pancreatitis. Fu, K., Sarras, M.P., De Lisle, R.C., Andrews, G.K. Am. J. Physiol. (1997) [Pubmed]
The regulator PerR is involved in oxidative stress response and iron homeostasis and is necessary for full virulence of Streptococcus pyogenes. Ricci, S., Janulczyk, R., Björck, L. Infect. Immun. (2002) [Pubmed]
Aging-induced up-regulation of nuclear binding activities of oxidative stress responsive NF-kB transcription factor in mouse cardiac muscle. Helenius, M., Hänninen, M., Lehtinen, S.K., Salminen, A. J. Mol. Cell. Cardiol. (1996) [Pubmed]
Evidence of both extra- and intracellular cysteine targets of protein modification for activation of RET kinase. Akhand, A.A., Ikeyama, T., Akazawa, S., Kato, M., Hossain, K., Takeda, K., Suzuki, H., Takahashi, M., Nakashima, I. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
Urea-associated oxidative stress and Gadd153/CHOP induction. Zhang, Z., Yang, X.Y., Cohen, D.M. Am. J. Physiol. (1999) [Pubmed]

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