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Gene Review:

Sp110 - Sp110 nuclear body protein

Mus musculus

Synonyms: 5031415C07Rik, 52kDa, 5830484A20Rik, ENSMUSG00000075603, Ifi75, ...

Pan, H. et al., Thye, T. et al., Weichenhan, D. et al., Tosh, K. et al.

Weichenhan, Kunze, Winking, van Geel, Osoegawa, de Jong, Traut,

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Disease relevance of Sp110

Expression of the Ipr1 transgene in the sst1 susceptible macrophages limits the multiplication not only of M. tuberculosis but also of Listeria monocytogenes and switches a cell death pathway of the infected macrophages from necrosis to apoptosis [1].
BACKGROUND: After a recent report on the role of the Ipr1 gene in mediating innate immunity in a mouse model of Mycobacterium tuberculosis infection, the human Ipr1 homologue, Sp110, was considered a promising candidate for an association study in human tuberculosis [2].

High impact information on Sp110

Ipr1 is encoded within the sst1 locus and is expressed in the tuberculosis lung lesions and macrophages of sst1-resistant, but not sst1-susceptible mice [3].
We identified and analyzed the genes Sp100, Csprs, and Ifi75 in two members of the genus Mus, M. musculus and M. caroli [4].
Sp100-rs and Ifi75 are components of a repeat cluster that extends over 6-200 Mb of the M. musculus genome [4].
Our data indicate that the Ipr1 gene product might have a previously undocumented function in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death and pathogenesis [1].

Biological context of Sp110

Ipr1 gene mediates innate immunity to tuberculosis [1].

Anatomical context of Sp110

The Ipr1 gene is upregulated in the sst1 resistant macrophages after activation and infection, but it is not expressed in the sst1 susceptible macrophages [1].

References

Ipr1 gene mediates innate immunity to tuberculosis. Pan, H., Yan, B.S., Rojas, M., Shebzukhov, Y.V., Zhou, H., Kobzik, L., Higgins, D.E., Daly, M.J., Bloom, B.R., Kramnik, I. Nature (2005) [Pubmed]
No associations of human pulmonary tuberculosis with Sp110 variants. Thye, T., Browne, E.N., Chinbuah, M.A., Gyapong, J., Osei, I., Owusu-Dabo, E., Niemann, S., Rüsch-Gerdes, S., Horstmann, R.D., Meyer, C.G. J. Med. Genet. (2006) [Pubmed]
Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa. Tosh, K., Campbell, S.J., Fielding, K., Sillah, J., Bah, B., Gustafson, P., Manneh, K., Lisse, I., Sirugo, G., Bennett, S., Aaby, P., McAdam, K.P., Bah-Sow, O., Lienhardt, C., Kramnik, I., Hill, A.V. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
Source and component genes of a 6-200 Mb gene cluster in the house mouse. Weichenhan, D., Kunze, B., Winking, H., van Geel, M., Osoegawa, K., de Jong, P.J., Traut, W. Mamm. Genome (2001) [Pubmed]

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