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Gene Review:

Sephs1 - selenophosphate synthetase 1

Mus musculus

Synonyms: 1110046B24Rik, AA589574, AI505014, AW111620, SELD, ...

Mihara, H. et al., Cone, R.A. et al., Krishnamoorthy, T. et al., Cordero, M.L. et al.

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High impact information on Sephs1

Reverse transcriptase-polymerase chain reaction and Western blot analyses revealed that mSCL is cytosolic and predominantly exists in the liver, kidney, and testis, where mouse selenophosphate synthetase is also abundant, supporting the view that mSCL functions in cooperation with selenophosphate synthetase in selenoprotein synthesis [1].
Two high affinity sodium-dependent and PDC-sensitive glutamate (GLU) uptake systems are present in a whole brain synaptosomal preparation from adult C57BL/10 SPS/SPS normal mice [2].
Ten agents were tested - five detergents: nonionic (N9), cationic (benzalkonium chloride, BZK), anionic (sodium dodecylsulfate, SDS), the pair of detergents in C31G (C14AO and C16B); one surface active agent (chlorhexidine); two non-detergents (BufferGel, and sulfonated polystyrene, SPS); and HEC placebo gel (hydroxyethylcellulose) [3].

Analytical, diagnostic and therapeutic context of Sephs1

H4 S1ph may promote chromatin compaction, since deletion of SPS1 increases accessibility to antibody immunoprecipitation; furthermore, either deletion of Sps1 or an H4 S1A substitution results in increased DNA volume in nuclei within spores [4].

References

cDNA cloning, purification, and characterization of mouse liver selenocysteine lyase. Candidate for selenium delivery protein in selenoprotein synthesis. Mihara, H., Kurihara, T., Watanabe, T., Yoshimura, T., Esaki, N. J. Biol. Chem. (2000) [Pubmed]
High affinity [3H]glutamate uptake systems in normal and audiogenic seizure-susceptible mice. Cordero, M.L., Ortiz, J.G., Santiago, G. Brain Res. Dev. Brain Res. (1994) [Pubmed]
Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission. Cone, R.A., Hoen, T., Wong, X., Abusuwwa, R., Anderson, D.J., Moench, T.R. BMC Infect. Dis. (2006) [Pubmed]
Phosphorylation of histone H4 Ser1 regulates sporulation in yeast and is conserved in fly and mouse spermatogenesis. Krishnamoorthy, T., Chen, X., Govin, J., Cheung, W.L., Dorsey, J., Schindler, K., Winter, E., Allis, C.D., Guacci, V., Khochbin, S., Fuller, M.T., Berger, S.L. Genes Dev. (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP007967	Anopheles gambiae str. PEST
SEPHS1	Bos taurus
seld-1	Caenorhabditis elegans
SEPHS1	Canis lupus familiaris
sephs1	Danio rerio
SelD	Drosophila melanogaster
SEPHS1	Gallus gallus
SEPHS1	Homo sapiens
SEPHS1	Macaca mulatta
SEPHS1	Pan troglodytes
Sephs1	Rattus norvegicus
sephs1	Xenopus (Silurana) tropicalis

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