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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Pkn2  -  protein kinase N2

Mus musculus

Synonyms: 6030436C20Rik, AI507382, PKN gamma, PRK2, Prk2, ...
 
 
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Disease relevance of Pkn2

 

High impact information on Pkn2

  • Atypical PKC isoforms, such as PKCzeta, and the PKC-related kinases, like PRK2, are also activated by phosphorylation of their T-loop site but, instead of possessing a phosphorylatable Ser/Thr in their hydrophobic motif, contain an acidic residue [2].
  • Using interspecific backcross analysis the Prk2 gene was mapped to mouse chromosome 3 [1].
  • PRK2 also specifically bound to Rho in a GTP-dependent manner and cooperated with Rho family proteins to induce transcriptional activation via the serum response factor [1].

References

  1. Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling. Quilliam, L.A., Lambert, Q.T., Mickelson-Young, L.A., Westwick, J.K., Sparks, A.B., Kay, B.K., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Der, C.J. J. Biol. Chem. (1996) [Pubmed]
  2. A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1. Balendran, A., Biondi, R.M., Cheung, P.C., Casamayor, A., Deak, M., Alessi, D.R. J. Biol. Chem. (2000) [Pubmed]
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