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Gene Review

Rmcf  -  resistance to MCF virus

Mus musculus

 
 
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Disease relevance of Rmcf

  • The Rmcf gene may be of much use as a means of determining the role of MCF viruses in various forms of leukemogenesis [1].
  • Differential disease restriction of Moloney and Friend murine leukemia viruses by the mouse Rmcf gene is governed by the viral long terminal repeat [2].
  • A population of murine hematopoietic progenitors expresses an endogenous retroviral gp70 linked to the Rmcf gene and associated with resistance to erythroleukemia [3].
  • The Rmcf gene restricts the replication of recombinant murine mink cell focus-inducing (MCF) viruses in cell cultures derived from mice carrying the resistance allele (Rmcfr) and may play a role in resistance to retrovirus-induced leukemias in vivo [4].
  • This study identifies an Rmcf-linked MCF provirus and indicates that, like the ecotropic virus resistance gene Fv4, Rmcf may mediate resistance through an interference mechanism [5].
 

High impact information on Rmcf

  • Previous studies suggested that Rmcf resistance is mediated by expression of an interfering MCF MLV envelope (Env) gene [5].
  • Characterization of a polytropic murine leukemia virus proviral sequence associated with the virus resistance gene Rmcf of DBA/2 mice [5].
  • Tests of association with marker loci already typed in the AKXD RI strains suggested that two loci, Rmcf and Pmv-25 (or a locus linked to Pmv-25), influence all three trait variables [6].
  • One gene correlated with the expression of an endogenous gp70 linked to the Rmcf gene and might act by viral interference [7].
  • Genetic experiments designed to characterize Sxv show that this gene also controls sensitivity to a wild mouse virus with the interference properties of mink cell focus-forming murine leukemia viruses, and that Sxv-mediated susceptibility to xenotropic murine leukemia viruses is restricted by the mink cell focus-forming virus resistance gene Rmcf [8].
 

Analytical, diagnostic and therapeutic context of Rmcf

  • Previously we reported that in cell cultures from first backcross progeny, this Rmcf-linked restriction segregates with the expression of an endogenous retroviral gp70 serologically related to that of MCF viruses [9].

References

  1. A mouse gene on chromosome 5 that restricts infectivity of mink cell focus-forming recombinant murine leukemia viruses. Hartley, J.W., Yetter, R.A., Morse, H.C. J. Exp. Med. (1983) [Pubmed]
  2. Differential disease restriction of Moloney and Friend murine leukemia viruses by the mouse Rmcf gene is governed by the viral long terminal repeat. Brightman, B.K., Li, Q.X., Trepp, D.J., Fan, H. J. Exp. Med. (1991) [Pubmed]
  3. A population of murine hematopoietic progenitors expresses an endogenous retroviral gp70 linked to the Rmcf gene and associated with resistance to erythroleukemia. Buller, R.S., Van Zant, G., Eldridge, P.W., Portis, J.L. J. Exp. Med. (1989) [Pubmed]
  4. Identification of two forms of an endogenous murine retroviral env gene linked to the Rmcf locus. Buller, R.S., Ahmed, A., Portis, J.L. J. Virol. (1987) [Pubmed]
  5. Characterization of a polytropic murine leukemia virus proviral sequence associated with the virus resistance gene Rmcf of DBA/2 mice. Jung, Y.T., Lyu, M.S., Buckler-White, A., Kozak, C.A. J. Virol. (2002) [Pubmed]
  6. Susceptibility of AKXD recombinant inbred mouse strains to lymphomas. Gilbert, D.J., Neumann, P.E., Taylor, B.A., Jenkins, N.A., Copeland, N.G. J. Virol. (1993) [Pubmed]
  7. Host genes conferring resistance to a central nervous system disease induced by a polytropic recombinant Friend murine retrovirus. Buller, R.S., Wehrly, K., Portis, J.L., Chesebro, B. J. Virol. (1990) [Pubmed]
  8. Susceptibility of wild mouse cells to exogenous infection with xenotropic leukemia viruses: control by a single dominant locus on chromosome 1. Kozak, C.A. J. Virol. (1985) [Pubmed]
  9. The endogenous mink cell focus-forming (MCF) gp70 linked to the Rmcf gene restricts MCF virus replication in vivo and provides partial resistance to erythroleukemia induced by Friend murine leukemia virus. Buller, R.S., Sitbon, M., Portis, J.L. J. Exp. Med. (1988) [Pubmed]
 
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