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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Kif22  -  kinesin family member 22

Mus musculus

Synonyms: AU021460, C81217, Kid, Kif22a, Kinesin-like protein KIF22
 
 
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Disease relevance of Kif22

  • Kid expressed in mammalian cells, as well as Kid expressed in Escherichia coli, was found to be monomeric [1].
 

High impact information on Kif22

  • The second microtubule-binding site would be important to enhance the affinity to microtubules for the monomeric motor, Kid [1].
  • Because the amino acid sequence of this region is highly conserved among species, it seems to have essential roles for the functions of Kid in vivo [1].
  • Development of lung tumors can be observed in Kid: CFLP mice treated intragastrically with diethyl pyrocarbonate and ammonia [2].
  • Mice infected with 200 Trichinella spiralis larvae were killed at 3-69 days post infection (dpi) and the jejunum and masseter muscles were sectioned in a cryostat and examined in the Tunell method with "In situ Cell Detected Kid POD" of Boehringer-Mannheim [3].

References

  1. The second microtubule-binding site of monomeric kid enhances the microtubule affinity. Shiroguchi, K., Ohsugi, M., Edamatsu, M., Yamamoto, T., Toyoshima, Y.Y. J. Biol. Chem. (2003) [Pubmed]
  2. Possible in vivo formation of a carcinogenic substance from diethyl pyrocarbonate and ammonia. Uzvölgyi, E., Boján, F. J. Cancer Res. Clin. Oncol. (1980) [Pubmed]
  3. The phenomenon of apoptosis in the course of experimental trichinellosis in mice. Karmańska, K., Houszka, M., Piekarska, J. Wiadomości parazytologiczne. (2000) [Pubmed]
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