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Gene Review

SCO5082  -  transcriptional regulator

Streptomyces coelicolor A3(2)

Synonyms: SCBAC28G1.08c, actII-1
 
 
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Disease relevance of SCO5082

  • Induction of ppGpp synthesis in Streptomyces coelicolor A3(2) grown under conditions of nutritional sufficiency elicits actII-ORF4 transcription and actinorhodin biosynthesis [1].
  • Deletion of the actII-ORF4 activator gene from one such plasmid in Saccharopolyspora erythraea drastically reduced expression from the cognate actI promoter, showing that host factors are required for optimal production of the activator protein itself [2].
 

High impact information on SCO5082

  • Here we describe the identification and characterization of a transcription factor, designated AtrA, that regulates transcription of actII-ORF4, the pathway-specific activator of the actinorhodin biosynthetic gene cluster in S. coelicolor [3].
  • The increase in actII-ORF4 expression was followed by transcription of the biosynthetic structural genes actIII and actVI-ORF1, and by the production of actinorhodin [4].
  • The mutant phenotype could be made to revert with extra copies of the wild-type actII-ORF4 gene but not with the actII-ORF4-177 mutant [5].
  • Analysis of expression of two genes coding for pathway-specific transcriptional regulators of actinorhodin and undecylprodigiosin synthesis, actII-ORF4 and redD, revealed that their expression is similarly differentially affected [6].
  • Gene-expression analysis revealed that introduction of rif into S. lividans elevates expression of the pathway-specific regulatory gene actII-ORF4 to nearly the same level seen in Streptomyces coelicolor [7].
 

Biological context of SCO5082

 

Associations of SCO5082 with chemical compounds

  • While most rRNA cDNA clones displayed adenosine homopolymer tails, the poly(A) tails of three rRNAs and all the redD and actII-orf4 clones consisted of a variety of heteropolymers [9].

References

  1. Induction of ppGpp synthesis in Streptomyces coelicolor A3(2) grown under conditions of nutritional sufficiency elicits actII-ORF4 transcription and actinorhodin biosynthesis. Hesketh, A., Sun, J., Bibb, M. Mol. Microbiol. (2001) [Pubmed]
  2. Increasing the efficiency of heterologous promoters in actinomycetes. Wilkinson, C.J., Hughes-Thomas, Z.A., Martin, C.J., Böhm, I., Mironenko, T., Deacon, M., Wheatcroft, M., Wirtz, G., Staunton, J., Leadlay, P.F. J. Mol. Microbiol. Biotechnol. (2002) [Pubmed]
  3. Transcriptional activation of the pathway-specific regulator of the actinorhodin biosynthetic genes in Streptomyces coelicolor. Uguru, G.C., Stephens, K.E., Stead, J.A., Towle, J.E., Baumberg, S., McDowall, K.J. Mol. Microbiol. (2005) [Pubmed]
  4. Stationary-phase production of the antibiotic actinorhodin in Streptomyces coelicolor A3(2) is transcriptionally regulated. Gramajo, H.C., Takano, E., Bibb, M.J. Mol. Microbiol. (1993) [Pubmed]
  5. Characterization of the pathway-specific positive transcriptional regulator for actinorhodin biosynthesis in Streptomyces coelicolor A3(2) as a DNA-binding protein. Arias, P., Fernández-Moreno, M.A., Malpartida, F. J. Bacteriol. (1999) [Pubmed]
  6. Differential production of two antibiotics of Streptomyces coelicolor A3(2), actinorhodin and undecylprodigiosin, upon salt stress conditions. Sevcikova, B., Kormanec, J. Arch. Microbiol. (2004) [Pubmed]
  7. Genetic and physiological characterization of rpoB mutations that activate antibiotic production in Streptomyces lividans. Lai, C., Xu, J., Tozawa, Y., Okamoto-Hosoya, Y., Yao, X., Ochi, K. Microbiology (Reading, Engl.) (2002) [Pubmed]
  8. Transcriptional organization and regulation of an antibiotic export complex in the producing Streptomyces culture. Caballero, J.L., Malpartida, F., Hopwood, D.A. Mol. Gen. Genet. (1991) [Pubmed]
  9. cDNA cloning confirms the polyadenylation of RNA decay intermediates in Streptomyces coelicolor. Bralley, P., Jones, G.H. Microbiology (Reading, Engl.) (2002) [Pubmed]
  10. Streptomycin production by Streptomyces griseus can be modulated by a mechanism not associated with change in the adpA component of the A-factor cascade. Hong, B., Phornphisutthimas, S., Tilley, E., Baumberg, S., McDowall, K.J. Biotechnol. Lett. (2007) [Pubmed]
 
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