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Fdps  -  farnesyl diphosphate synthetase

Mus musculus

Synonyms: (2E,6E)-farnesyl diphosphate synthase, 6030492I17Rik, AI256750, CR 39, Cholesterol-regulated 39 kDa protein, ...
 
 
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High impact information on Fdps

  • Somatic cell hybrid studies and in situ hybridization show that the human genome contains five distinct loci that hybridize to the cDNA for the enzyme farnesyl pyrophosphate synthetase (FPS), a prenyltransferase that catalyzes the synthesis of an intermediate common to both the sterol and the nonsterol branches of the isoprene biosynthetic pathway [1].
  • We report here the chromosomal mapping of nine loci in the mouse that hybridize to the cDNA for the enzyme farnesyl pyrophosphate synthetase (FPS), a prenyltransferase that catalyzes the synthesis of an intermediate common to both the sterol and nonsterol branches of the isoprene biosynthetic pathway [2].
  • Treatment with FPS resulted in significant decreases in the percentage of eosinophils and neutrophils in bronchoalveolar lavage fluid and in lung pathology compared to FP or Sal [3].
  • METHODS: Since the effectiveness of corticosteroids in treating RSV infection has been controversial, we tested fluticasone propionate (FP) and salmeterol (Sal) alone versus FP plus Sal (FPS) on RSV-induced airway inflammation [3].
 

Anatomical context of Fdps

  • FPS treatment of mice infected with RSV in the absence of allergen sensitization resulted in a 50% decrease of RSV titer in the lung and a reduction in neutrophils compared to FP or Sal [3].
 

Analytical, diagnostic and therapeutic context of Fdps

  • The investigation of boron biodistribution by neutron induced autoradiography was performed using a CR-39 etched track detector [4].
  • For the study on boron neutron capture therapy, the whole-body sections of tumor-bearing mice infused with 10B attached to CR-39 plastic track detectors were exposed to thermal and cold neutron beams [5].

References

  1. Dispersed family of human genes with sequence similarity to farnesyl pyrophosphate synthetase. Heinzmann, C., Clarke, C.F., Klisak, I., Mohandas, T., Sparkes, R.S., Edwards, P.A., Lusis, A.J. Genomics (1989) [Pubmed]
  2. Mapping of multiple mouse loci related to the farnesyl pyrophosphate synthetase gene. Andalibi, A., Diep, A., Quon, D., Mohandas, T., Taylor, B.A., Lusis, A.J. Mamm. Genome (1993) [Pubmed]
  3. Combined fluticasone propionate and salmeterol reduces RSV infection more effectively than either of them alone in allergen-sensitized mice. Singam, R., Jena, P.K., Behera, S., Hellermann, G.R., Lockey, R.F., Ledford, D., Mohapatra, S.S. Virol. J. (2006) [Pubmed]
  4. Selective radiography of 10B distribution in organs using cold and thermal neutron beams. Skvarc, J., Giacomelli, M., Yanagië, H., Kühne, G. Cell. Mol. Biol. Lett. (2002) [Pubmed]
  5. Neutron capture autoradiographic study of the biodistribution of 10B in tumor-bearing mice. Ogura, K., Yanagie, H., Eriguchi, M., Lehmann, E.H., Kühne, G., Bayon, G., Kobayashi, H. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. (2004) [Pubmed]
 
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