The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Tas1r1  -  taste receptor, type 1, member 1

Mus musculus

Synonyms: G-protein coupled receptor 70, Gpr70, T1R1, T1r1, TR1, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Tas1r1

 

High impact information on Tas1r1

  • We propose to use the term Tr1 cells for all IL-10-producing T-cell populations that are induced by IL-10 and have regulatory activity [2].
  • This study further analyzes the role of B7H1 in differentiation of type 1 T regulatory (Tr1) cells and explores underlying mechanisms [1].
  • B7H1-Ig-treated CD4(+) T cells were found to activate a characteristic Tr1 population possessing a CD4(+)CD25(-)Foxp3(-) CD45RB(low) phenotype [1].
  • Furthermore, results from clinical protocols using Tr1 cells to modulate immune responses in vivo in autoimmunity, transplantation, and chronic inflammatory diseases will undoubtedly prove the biological relevance of these cells in immunotolerance [2].
  • In contrast to the naturally occurring CD4+ CD25+ T regulatory cells (Tregs) that emerge directly from the thymus, Tr1 cells are induced by antigen stimulation via an IL-10-dependent process in vitro and in vivo [2].
 

Biological context of Tas1r1

  • Molecular genetics and heterologous expression implicate T1r2 plus T1r3 as a sweet-responsive receptor,and T1r1 plus T1r3,as well as a truncated form of the type 4 metabotropic glutamate receptor (taste-mGluR4),as umami-responsive receptors [3].
  • The splenic CD4-8- DC subset that secretes transforming growth factor (TGF)-beta stimulates CD4+ regulatory T type 1 (Tr1) cell responses, and this leads to antitumor immune tolerance [4].
 

Other interactions of Tas1r1

  • The Gpr70 gene maps proximal to Sac, which demonstrates that they are different loci [5].

References

  1. B7H1-Ig Fusion Protein Activates the CD4+ IFN-{gamma} Receptor+ Type 1 T Regulatory Subset through IFN-{gamma}-Secreting Th1 Cells. Ding, Q., Lu, L., Wang, B., Zhou, Y., Jiang, Y., Zhou, X., Xin, L., Jiao, Z., Chou, K.Y. J. Immunol. (2006) [Pubmed]
  2. Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Roncarolo, M.G., Gregori, S., Battaglia, M., Bacchetta, R., Fleischhauer, K., Levings, M.K. Immunol. Rev. (2006) [Pubmed]
  3. Detection of sweet and umami taste in the absence of taste receptor T1r3. Damak, S., Rong, M., Yasumatsu, K., Kokrashvili, Z., Varadarajan, V., Zou, S., Jiang, P., Ninomiya, Y., Margolskee, R.F. Science (2003) [Pubmed]
  4. Conversion of tolerogenic CD4-8- dendritic cells to immunogenic ones inducing efficient antitumor immunity. Zhang, X., Moyana, T., Quereshi, M., Xiang, J. Cancer Biother. Radiopharm. (2006) [Pubmed]
  5. High-resolution genetic mapping of the saccharin preference locus (Sac) and the putative sweet taste receptor (T1R1) gene (Gpr70) to mouse distal Chromosome 4. Li, X., Inoue, M., Reed, D.R., Huque, T., Puchalski, R.B., Tordoff, M.G., Ninomiya, Y., Beauchamp, G.K., Bachmanov, A.A. Mamm. Genome (2001) [Pubmed]
 
WikiGenes - Universities