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Gene Review:

patA - two-component response regulator,...

Nostoc sp. PCC 7120

Liang, J. et al., Wolk, C.P., Orozco, C.C. et al.

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Disease relevance of patA

The patA mutation suppresses the multiheterocyst phenotype produced by extra copies of the wild-type hetR gene described previously, suggesting that PatA and HetR are components of the same environment-sensing regulatory circuit in Anabaena [1].
The patA gene product, which contains a region similar to CheY of Escherichia coli, controls heterocyst pattern formation in the cyanobacterium Anabaena 7120 [1].

High impact information on patA

Mature and developing heterocysts inhibit nearby vegetative cells from differentiating; genes patA, devA, hetC, and the hetMNI locus may hold keys to understanding intercellular interactions that influence heterocyst formation [2].
A functional patS gene was necessary for the delayed multiple-contiguous-heterocyst phenotype observed in hetN mutants as well as for the relative lack of intercalary heterocysts in patA mutants [3].

References

The patA gene product, which contains a region similar to CheY of Escherichia coli, controls heterocyst pattern formation in the cyanobacterium Anabaena 7120. Liang, J., Scappino, L., Haselkorn, R. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
Heterocyst formation. Wolk, C.P. Annu. Rev. Genet. (1996) [Pubmed]
Epistasis analysis of four genes from Anabaena sp. strain PCC 7120 suggests a connection between PatA and PatS in heterocyst pattern formation. Orozco, C.C., Risser, D.D., Callahan, S.M. J. Bacteriol. (2006) [Pubmed]

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