Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

xisC - hupL element site-specific recombinase

Nostoc sp. PCC 7120

Carrasco, C.D. et al., Carrasco, C.D. et al.

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Disease relevance of xisC

Heterocyst-specific excision of the Anabaena sp. strain PCC 7120 hupL element requires xisC [1].
Expression of xisC in Escherichia coli was sufficient to produce rearrangement of an artificial substrate plasmid bearing the hupL element recombination sites [1].

High impact information on xisC

An open reading frame, named xisC, identified near one end of the hupL DNA element is presumed to encode the element's site-specific recombinase [2].
Overexpression of xisC from a plasmid in a wild-type background caused a low level of hupL rearrangement even in nitrogen-replete conditions [1].

Regulatory relationships of xisC

A strain in which the xisC gene was inactivated showed no detectable excision of the hupL element. hupL encodes the large subunit of uptake hydrogenase [1].

References

Heterocyst-specific excision of the Anabaena sp. strain PCC 7120 hupL element requires xisC. Carrasco, C.D., Holliday, S.D., Hansel, A., Lindblad, P., Golden, J.W. J. Bacteriol. (2005) [Pubmed]
Programmed DNA rearrangement of a cyanobacterial hupL gene in heterocysts. Carrasco, C.D., Buettner, J.A., Golden, J.W. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]

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