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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

H2-Q6  -  histocompatibility 2, Q region locus 6

Mus musculus

Synonyms: 0610037M15Rik, H-2Q6, Qa-6, Qa6
 
 
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High impact information on H2-Q6

  • In this report, we address the biochemical relationships among Qa-2, Qa-6, and the 20-8-4 cross-reactive molecule by using immunoprecipitation and polyacrylamide gel electrophoresis [1].
  • The Qa-6 alloantigen and the molecule that crossreacts with the monoclonal antibody (mAb) 20-8-4 have been shown to be serologically distinct from the Qa-2 alloantigen by strain distribution and tissue distribution, respectively [1].
  • Specific antisera against Qa-6, in the presence of complement, lyses approximately 40% of lymph-node lymphocytes and splenocytes [2].
  • Strain distribution analyses indicate that Qa-6 is specified by a gene within the TL subregion of the major histocompatibility complex [2].
 

Analytical, diagnostic and therapeutic context of H2-Q6

References

  1. Biochemical characterization of the molecules reactive with Qa-6 antiserum and the monoclonal antibody 20-8-4: evidence for structural similarity with the Qa-2 molecule. Widacki, S.M., Flaherty, L., Cook, R.G. J. Immunol. (1985) [Pubmed]
  2. Syngeneic tumor immunizations produce Qa antibodies. Discovery of a new Qa antigen, Qa-6. Flaherty, L., Karl, M., Reinisch, C.L. Immunogenetics (1982) [Pubmed]
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