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Gene Review: 

patB  -  transcriptional regulator

Nostoc sp. PCC 7120

 
 
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Disease relevance of patB

  • The patB gene product, required for growth of the cyanobacterium Anabaena sp. strain PCC 7120 under nitrogen-limiting conditions, contains ferredoxin and helix-turn-helix domains [1].
 

High impact information on patB

  • Heterocyst-specific expression of patB, a gene required for nitrogen fixation in Anabaena sp. strain PCC 7120 [2].
  • The mutation in strain PAT-2 is the deletion of G at nucleotide 1342 in the patB gene, resulting in the loss of a 62-amino-acid fragment from the C terminus of the PatB protein, including the helix-turn-helix motif [1].
 

Biological context of patB

  • A patB deletion mutant suffers an almost complete cessation of growth and nitrogen fixation within 24 h of combined nitrogen removal [2].

References

  1. The patB gene product, required for growth of the cyanobacterium Anabaena sp. strain PCC 7120 under nitrogen-limiting conditions, contains ferredoxin and helix-turn-helix domains. Liang, J., Scappino, L., Haselkorn, R. J. Bacteriol. (1993) [Pubmed]
  2. Heterocyst-specific expression of patB, a gene required for nitrogen fixation in Anabaena sp. strain PCC 7120. Jones, K.M., Buikema, W.J., Haselkorn, R. J. Bacteriol. (2003) [Pubmed]
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