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Gene Review

Atxn3  -  ataxin 3

Mus musculus

Synonyms: 2210008M02Rik, AI463012, AI647473, ATX3, Ataxin-3, ...
 
 
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Disease relevance of Atxn3

 

High impact information on Atxn3

  • We have previously reported the generation of human yeast artificial chromosome (YAC) constructs encompassing the MJD1 locus into which expanded (CAG)(76) and (CAG)(84) repeat motifs have been introduced by homologous recombination [3].
  • A neuroendocrine dysfunction, not testicular mutant ataxin-3 cleavage fragment or aggregate, causes cell death in testes of transgenic mice [4].
  • Transient overexpression of CHIP increases the ubiquitination and the rate of degradation of polyglutamine-expanded huntingtin or ataxin-3 [5].
  • Upon differentiation of P19 cells, the Mjd gene promoter is preferentially activated in endodermal and mesodermal derivatives, including cardiac and skeletal myocytes; and less so in neuronal precursors [6].
  • Mouse ataxin-3 is ubiquitously expressed during embryonic development and in the adult, with strong expression in regions of the CNS affected in MJD [6].
 

Biological context of Atxn3

 

Other interactions of Atxn3

References

  1. Difference in obesity phenotype between orexin-knockout mice and orexin neuron-deficient mice with same genetic background and environmental conditions. Hara, J., Yanagisawa, M., Sakurai, T. Neurosci. Lett. (2005) [Pubmed]
  2. Misfolding promotes the ubiquitination of polyglutamine-expanded ataxin-3, the defective gene product in SCA3/MJD. Jana, N.R., Nukina, N. Neurotoxicity research. (2004) [Pubmed]
  3. YAC transgenic mice carrying pathological alleles of the MJD1 locus exhibit a mild and slowly progressive cerebellar deficit. Cemal, C.K., Carroll, C.J., Lawrence, L., Lowrie, M.B., Ruddle, P., Al-Mahdawi, S., King, R.H., Pook, M.A., Huxley, C., Chamberlain, S. Hum. Mol. Genet. (2002) [Pubmed]
  4. A neuroendocrine dysfunction, not testicular mutant ataxin-3 cleavage fragment or aggregate, causes cell death in testes of transgenic mice. Colomer Gould, V.F., Goti, D., Kiluk, J. Cell Death Differ. (2006) [Pubmed]
  5. Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes. Jana, N.R., Dikshit, P., Goswami, A., Kotliarova, S., Murata, S., Tanaka, K., Nukina, N. J. Biol. Chem. (2005) [Pubmed]
  6. Genomic structure, promoter activity, and developmental expression of the mouse homologue of the Machado-Joseph disease (MJD) gene. do Carmo Costa, M., Gomes-da-Silva, J., Miranda, C.J., Sequeiros, J., Santos, M.M., Maciel, P. Genomics (2004) [Pubmed]
  7. Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype. Bewick, G.A., Gardiner, J.V., Dhillo, W.S., Kent, A.S., White, N.E., Webster, Z., Ghatei, M.A., Bloom, S.R. FASEB J. (2005) [Pubmed]
  8. Reduced food anticipatory activity in genetically orexin (hypocretin) neuron-ablated mice. Akiyama, M., Yuasa, T., Hayasaka, N., Horikawa, K., Sakurai, T., Shibata, S. Eur. J. Neurosci. (2004) [Pubmed]
 
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