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Gene Review

nucA  -  sugar-non-specific nuclease

Nostoc sp. PCC 7120

 
 
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Disease relevance of nucA

 

High impact information on nucA

  • Immediately downstream from the nucA gene, in the complementary strand, we have identified an open reading frame composed of 135 codons, that we have named nuiA, whose expression in E. coli conferred heat-resistant NucA-inhibitory activity to cell-free extracts [2].
  • The 410-kb alpha megaplasmid of the heterocyst-forming cyanobacterium Anabaena sp. strain PCC 7120 was found to bear the nucA gene that encodes a sugar-nonspecific nuclease [3].
 

Anatomical context of nucA

  • With all constructs, tandem expression of nucA and nuiA results in aggregation and inclusion body formation of NucA, independent of the order of the genes, the relative expression of the two proteins and the temperature applied during expression [4].
 

Analytical, diagnostic and therapeutic context of nucA

References

  1. Identification, genetic analysis and characterization of a sugar-non-specific nuclease from the cyanobacterium Anabaena sp. PCC 7120. Muro-Pastor, A.M., Flores, E., Herrero, A., Wolk, C.P. Mol. Microbiol. (1992) [Pubmed]
  2. The nuiA gene from Anabaena sp. encoding an inhibitor of the NucA sugar-non-specific nuclease. Muro-Pastor, A.M., Herrero, A., Flores, E. J. Mol. Biol. (1997) [Pubmed]
  3. Transfer of a genetic marker from a megaplasmid of Anabaena sp. strain PCC 7120 to a megaplasmid of a different Anabaena strain. Muro-Pastor, A.M., Kuritz, T., Flores, E., Herrero, A., Wolk, C.P. J. Bacteriol. (1994) [Pubmed]
  4. Genetic engineering of Escherichia coli to produce a 1:1 complex of the anabaena sp. PCC 7120 nuclease NucA and its inhibitor NuiA. Korn, C., Meiss, G., Gast, F., Gimadutdinow, O., Urbanke, C., Pingoud, A. Gene (2000) [Pubmed]
 
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