Disease relevance of Saa

• Saa exhibits a low degree of similarity (25% amino acid [aa] identity) with YadA of Yersinia enterocolitica and Eib, a recently described phage-encoded immunoglobulin binding protein from E. coli [1].

High impact information on Saa

• Saa produced by 98NK2 is 516 aa long and includes four copies of a 37-aa direct repeat sequence [1].
• Similar to other Saa family members, it has four exons and three introns [2].
• It is 4588 bp long from the transcription start site to the end of the 3'-untranslated region and is approximately 20% larger than other Saa genes [2].
• DNA sequence analysis identified clone C122 as murine serum amyloid A 3 (Saa3), a member of the Saa family of acute-phase or inflammatory response genes [3].
• Saa message levels were then examined in vivo in the bone marrow of mice exposed to total-body irradiation [3].

Other interactions of Saa

• Structural variation in serum amyloid A correlated with restriction fragment length polymorphisms in the Saa gene determined by Taylor and Rowe (1984) [4].

References