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Gene Review:

Emv12 - endogenous ecotropic MuLV 12

Mus musculus

Synonyms: Akv-2, Emv-12

Kozak, C.A., Kozak, C.A. et al., Staal, S.P. et al., Hartley, J.W. et al., Cloyd, M.W. et al., et al.

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Disease relevance of Emv12

Akv-1 and Akv-2 (Emv-12), an ecotropic provirus carried by AKR/N but not AKR/J, have previously been mapped to chromosome 7 and 16, respectively [1].
This assignment of Akv-2 further emphasizes the endogenous ecotropic retroviruses are inserted at multiple sites in mouse chromosomes [2].
MCF lymphomagenicity was strain specific, however, in that AKR MCF viruses did not induce lymphomas in many murine strains; they were moderately lymphomagenic in C3H/Bi mice and in National Institutes of Health Swiss partially congenic for Akv-1 or Akv-2 [3].
Murine leukemia viruses capable of malignant transformation of mink tissue culture cells have been isolated from an AKR thymoma cell line and from a spontaneous reticulum cell sarcoma in an NIH Swiss mouse partially congenic for the AKR ecotropic virus-inducing locus Akv-2 [4].

High impact information on Emv12

(AKR x NZB)F1 mice possess the dominant genes, Akv-1, Akv-2, Nzv-1a and Nzv-2a, which determine the expression of ecotropic and xenotropic viruses [5].
A combination of somatic cell hybridization and standard mendelian breeding techniques was used to map the AKR ecotropic virus inducibility locus Akv-2 to the centromeric end of chromosome 16 [2].
A new type of murine leukemia virus has been detected in thymuses of leukemic and late preleukemic AKR mice, in lymphomas developing in NIH Swiss mice carrying the AKR ectopic virus-inducing loci Akv-I or Akv-2, and in the thymus of a preleukemic C58 mouse [6].
The A alpha subunits of B10.STC90 (Akv1) and W12A (Akv2) differ from those of B10.BR (Ak) in two adjacent tryptic peptides spanning positions 43 to 71 in the alpha 1 domain [7].
After induction, hybrids with Bxv-1 produced only a transient burst of virus, whereas those with Akv-2 continued to produce virus for periods in excess of 3 months [8].

Biological context of Emv12

Moreover, cells from the congenic strain L.AKR-Akv-2, which carried the Akv-2 genome on a C57L background, also showed thymidine transport [9].

Other interactions of Emv12

No recombinants between the Igl-1 locus and Akv-2 were found by Southern blot analysis of DNA obtained from progeny of the backcross of (AKR/N X SJL/J)F1 to SJL/J, indicating that these genes map within 5.9 cM of each other [10].
RNase T1-resistant oligonucleotides of Akv-1 and Akv-2 type C viruses of AKR mice [11].

References

Chromosomal assignment of two endogenous ecotropic murine leukemia virus proviruses of the AKR/J mouse strain. Taylor, B.A., Rowe, L., Jenkins, N.A., Copeland, N.G. J. Virol. (1985) [Pubmed]
Genetic mapping of the ecotropic virus-inducing locus Akv-2 of the AKR mouse. Kozak, C.A., Rowe, W.P. J. Exp. Med. (1980) [Pubmed]
Lymphomagenicity of recombinant mink cell focus-inducing murine leukemia viruses. Cloyd, M.W., Hartley, J.W., Rowe, W.P. J. Exp. Med. (1980) [Pubmed]
Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma. Staal, S.P., Hartley, J.W., Rowe, W.P. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
Phenotypic alteration in retroviral gene expression by leukemia-resistant thymocytes differentiating in leukemia-susceptible recipients. Datta, S.K., Waksal, S.D., Schwartz, R.S. Cell (1980) [Pubmed]
A new class of murine leukemia virus associated with development of spontaneous lymphomas. Hartley, J.W., Wolford, N.K., Old, L.J., Rowe, W.P. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
Localization of structural variations distinguishing I-Ak-related molecules to the alpha 1 and beta 1 domains. Wakeland, E.K., Darby, B., Coligan, J.E. J. Immunol. (1985) [Pubmed]
Differential expression of murine leukemia virus loci in chemically induced hybrid cells. Kozak, C.A. J. Virol. (1984) [Pubmed]
Plasma membrane mediated thymidine transport in AKR spleen cells. Strauss, P.R., Sheehan, J.M., Taylor, J. Can. J. Biochem. (1980) [Pubmed]
Linkage of the Igl-1 structural and regulatory genes to Akv-2 on chromosome 16. Epstein, R., Lehmann, K., Cohn, M., Buckler, C., Rowe, W., Davisson, M. Immunogenetics (1984) [Pubmed]
RNase T1-resistant oligonucleotides of Akv-1 and Akv-2 type C viruses of AKR mice. Rommelaere, J., Faller, D.V., Hopkins, N. J. Virol. (1977) [Pubmed]

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