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Gene Review:

Derm1 - dermititis 1

Mus musculus

Rhim, J.S. et al., Chakraborty, A.K. et al., Jones, J.C. et al., Kawashima, T. et al.

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Disease relevance of Derm1

A horse skin cell line (E. Derm, NBL-6, CCL-57) was susceptible to focus formation by the Kirsten mouse sarcoma virus, feline sarcoma virus (ST stain) and the MSV pseudotypes with woolly monkey, gibbon monkey, RD-114, AT-124, baboon placenta and murine xenotropic (BALB/c 3T3 and C57L/JD) type-C viruses [1].
Ultraviolet B light (UVB) acted synergistically with MSH to increase tyrosinase activity and melanin content of cultured Cloudman melanoma cells, consistent with previous findings in the skin of mice and guinea pigs (Bolognia et al: J. Invest. Derm., 92:651-656, 1989) [2].
We have also utilized bullous pemphigoid (BP) autoantibodies that have been shown to recognize hemidesmosomes in mammalian skin cells [Mutasim et al., J. Invest. Derm., 84:47-53, 1985] [3].

High impact information on Derm1

[J. invest. Derm. 82, 53 (1984)] in the same cell line exposed to 10(-4) M TBC [4].

References

Transformation of horse skin cells by type-C sarcoma viruses. Rhim, J.S., Ro, H.S., Kim, E.B., Gilden, R.V., Huebner, R.J. Int. J. Cancer (1975) [Pubmed]
Structural/functional relationships between internal and external MSH receptors: modulation of expression in Cloudman melanoma cells by UVB radiation. Chakraborty, A.K., Orlow, S.J., Bolognia, J.L., Pawelek, J.M. J. Cell. Physiol. (1991) [Pubmed]
Is the hemidesmosome a half desmosome? An immunological comparison of mammalian desmosomes and hemidesmosomes. Jones, J.C., Yokoo, K.M., Goldman, R.D. Cell Motil. Cytoskeleton (1986) [Pubmed]
Stimulation of pheomelanogenesis in cultured B16 melanoma cells by 4-tertiary butylcatechol. Kawashima, T., Halldin, M.M., Fukuyama, K., Castagnoli, N., Gellin, G.A., Epstein, W.L. Biochem. Pharmacol. (1985) [Pubmed]

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