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Gene Review:

Orch3 - autoimmune orchitis resistance 3

Mus musculus

Butterfield, R.J. et al., Person, P.L. et al.

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Disease relevance of Orch3

One locus, eae7, colocalizes to the same region of chromosome II as Orch3 and Idd4, susceptibility loci in autoimmune orchitis and insulin-dependent diabetes mellitus, respectively [1].

High impact information on Orch3

In addition, immunogenetic analyses have identified two immune suppression genes, Orch-2 and Orch-3, which control active immunoregulatory mechanisms governing the phenotypic expression of disease resistance [2].

References

New genetic loci that control susceptibility and symptoms of experimental allergic encephalomyelitis in inbred mice. Butterfield, R.J., Sudweeks, J.D., Blankenhorn, E.P., Korngold, R., Marini, J.C., Todd, J.A., Roper, R.J., Teuscher, C. J. Immunol. (1998) [Pubmed]
The immunogenetics of susceptibility and resistance to murine experimental allergic orchitis. Person, P.L., Snoek, M., Demant, P., Woodward, S.R., Teuscher, C. Regional immunology. (1992) [Pubmed]

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