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Gene Review

Orch1  -  autoimmune orchitis resistance 1

Mus musculus

Synonyms: Orch-1
 
 
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Disease relevance of Orch1

  • Susceptibility to experimental allergic orchitis, which is controlled by the Orch-1 locus, is one example [1].
  • Two of the other novel genes lie within a region syntenic to that implicated in susceptibility to experimental allergic orchitis in the mouse, an autoimmune disease of the testis, and represent additional candidates for the Orch-1 locus associated with this disease [2].
 

High impact information on Orch1

  • Heat shock proteins play an important role in a large number of physiological processes and it is tempting to speculate that Hsc70t, which exhibits testis-specific expression, may be identical to Orch-1 [1].
  • Three Hsp70 genes are located in the C4-H-2D region: possible candidates for the Orch-1 locus [1].
  • The results of the analysis indicate that Orch-1 maps within the interval between the H-2S and H-2D regions [3].
  • We have mapped one nonclassical immune response gene, orchitis susceptibility gene-1 (Orch-1), to an interval of ca. 100 kilobases within the H-2S-H-2D region [4].
 

Biological context of Orch1

  • A comparison of the Orch-1 alleles with the genotypes of two additional markers which map within the H-2S/H-2D interval suggests the following gene order: H-2S--TNP-Ficoll--Orch-1--Tnfa--H-2D [3].

References

  1. Three Hsp70 genes are located in the C4-H-2D region: possible candidates for the Orch-1 locus. Snoek, M., Jansen, M., Olavesen, M.G., Campbell, R.D., Teuscher, C., van Vugt, H. Genomics (1993) [Pubmed]
  2. Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II beta subunit (CSNK2B). Albertella, M.R., Jones, H., Thomson, W., Olavesen, M.G., Campbell, R.D. Genomics (1996) [Pubmed]
  3. Experimental allergic orchitis in mice. VI. Recombinations within the H-2S/H-2D interval define the map position of the H-2-associated locus controlling disease susceptibility. Teuscher, C., Gasser, D.L., Woodward, S.R., Hickey, W.F. Immunogenetics (1990) [Pubmed]
  4. The immunogenetics of susceptibility and resistance to murine experimental allergic orchitis. Person, P.L., Snoek, M., Demant, P., Woodward, S.R., Teuscher, C. Regional immunology. (1992) [Pubmed]
 
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