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Gene Review

Char2  -  P. chabaudi malaria resistance QTL 2

Mus musculus

 
 
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Disease relevance of Char2

 

High impact information on Char2

  • Recombinant congenic strains AcB55 and AcB61 are unusually resistant to malaria despite carrying susceptibility alleles at Char1 and Char2 [2].
  • One of the AcB strains, AcB55, is shown to be highly resistant to infection despite 83% susceptible A genomic composition, including susceptibility alleles at Char1 and Pchr/Char2 [3].

References

  1. Temporal expression of an H2-linked locus in host response to mouse malaria. Burt, R.A., Baldwin, T.M., Marshall, V.M., Foote, S.J. Immunogenetics (1999) [Pubmed]
  2. Pyruvate kinase deficiency in mice protects against malaria. Min-Oo, G., Fortin, A., Tam, M.F., Nantel, A., Stevenson, M.M., Gros, P. Nat. Genet. (2003) [Pubmed]
  3. Identification of a new malaria susceptibility locus (Char4) in recombinant congenic strains of mice. Fortin, A., Cardon, L.R., Tam, M., Skamene, E., Stevenson, M.M., Gros, P. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
 
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