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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Nup88  -  nucleoporin 88

Rattus norvegicus

Synonyms: 88 kDa nucleoporin, Nuclear pore complex protein Nup88, Nucleoporin Nup84, Nucleoporin Nup88, Nup84, ...
 
 
 
 
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High impact information on Nup88

  • Consistent with such an association, Nup84 is found to be exposed on the cytoplasmic face of the nuclear pore complex. cDNA sequence analyses indicate that Nup84 contains neither the GLFG nor the XFXFG repeats that are a characteristic of a number of other nuclear pore complex proteins [1].
 

Biological context of Nup88

  • Mutagenesis and expression studies indicate that the putative coiled-coil domain is required for association with the cytoplasmic face of the nuclear pore complex, whereas it is the NH2-terminal region of Nup84 that contains the site of interaction with CAN/Nup214 [1].
 

Anatomical context of Nup88

  • These findings suggest a model in which Nup84 may function in the attachment of CAN/Nup214 to the central framework of the nuclear pore complex [1].
 

Analytical, diagnostic and therapeutic context of Nup88

  • Immunoprecipitation studies carried out under nondenaturing conditions, and using a variety of antibodies, reveal a novel nonglycosylated nucleoporin, Nup84, that is tightly associated with CAN/Nup214 [1].

References

  1. Nup84, a novel nucleoporin that is associated with CAN/Nup214 on the cytoplasmic face of the nuclear pore complex. Bastos, R., Ribas de Pouplana, L., Enarson, M., Bodoor, K., Burke, B. J. Cell Biol. (1997) [Pubmed]
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