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efnb1  -  ephrin-B1

Danio rerio

Synonyms: SO:0000704
 
 
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Disease relevance of efnb1

 

High impact information on efnb1

  • Previous work has implicated Eph receptors and ephrin-B proteins in the restriction of cell intermingling between hindbrain segments [2].
  • Ephrin-B proteins have conserved cytoplasmic tyrosine residues that are phosphorylated upon interaction with an EphB receptor, and may transduce signals that regulate a cellular response [2].
  • Ephrin-B regulates the Ipsilateral routing of retinal axons at the optic chiasm [3].
  • Morphogenesis of prechordal plate and notochord requires intact Eph/ephrin B signaling [4].
  • Our observations suggest Eph/ephrin B signaling plays an essential role in regulating cell movements during gastrulation [4].
 

Biological context of efnb1

  • Because Eph receptors and ephrins have complementary expression in many tissues during embryogenesis, bidirectional activation of Eph receptors and ephrin-B proteins could occur at interfaces of their expression domains, for example at segment boundaries in the vertebrate hindbrain [2].
 

Anatomical context of efnb1

  • Ectopic overexpression of dominant-negative soluble ephrin B constructs yields reproducible defects in the morphology of the notochord and prechordal plate by the end of gastrulation [4].
  • Distribution of EphB receptors and ephrin-B1 in the developing vertebrate spinal cord [1].
  • Contact-dependent interactions between EphB receptors and ephrin-B ligands mediate a variety of cell-cell communication events in the developing and mature central nervous system (CNS) [1].

References

  1. Distribution of EphB receptors and ephrin-B1 in the developing vertebrate spinal cord. Jevince, A.R., Kadison, S.R., Pittman, A.J., Chien, C.B., Kaprielian, Z. J. Comp. Neurol. (2006) [Pubmed]
  2. Eph receptors and ephrins restrict cell intermingling and communication. Mellitzer, G., Xu, Q., Wilkinson, D.G. Nature (1999) [Pubmed]
  3. Ephrin-B regulates the Ipsilateral routing of retinal axons at the optic chiasm. Nakagawa, S., Brennan, C., Johnson, K.G., Shewan, D., Harris, W.A., Holt, C.E. Neuron (2000) [Pubmed]
  4. Morphogenesis of prechordal plate and notochord requires intact Eph/ephrin B signaling. Chan, J., Mably, J.D., Serluca, F.C., Chen, J.N., Goldstein, N.B., Thomas, M.C., Cleary, J.A., Brennan, C., Fishman, M.C., Roberts, T.M. Dev. Biol. (2001) [Pubmed]
 
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