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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

spry4  -  sprouty homolog 4 (Drosophila)

Danio rerio

Synonyms: SO:0000704, cb511, sprouty4, wu:fb92b06, zSpry4
 
 
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High impact information on spry4

  • These growth rates correlate with position-dependent differences in blastemal length, mitotic index and expression of the Fgf target genes mkp3, sef and spry4 [1].
  • Furthermore, inhibition of Fgf signaling by overexpression of sprouty4 or application of the Fgf inhibitor SU5402 leads to a loss of all erm and pea3 expression domains [2].
  • Recapitulating the knockdown phenotype using a second MO of independent sequence, absence of the phenotype using a mismatched MO sequence, and rescue of the phenotype by cDNA-based overexpression of the targeted transcript for zebrafish spry4 confirmed the specificity of MO targeting in this system [3].

References

  1. Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration. Lee, Y., Grill, S., Sanchez, A., Murphy-Ryan, M., Poss, K.D. Development (2005) [Pubmed]
  2. Tight transcriptional control of the ETS domain factors Erm and Pea3 by Fgf signaling during early zebrafish development. Raible, F., Brand, M. Mech. Dev. (2001) [Pubmed]
  3. Functional analysis of human hematopoietic stem cell gene expression using zebrafish. Eckfeldt, C.E., Mendenhall, E.M., Flynn, C.M., Wang, T.F., Pickart, M.A., Grindle, S.M., Ekker, S.C., Verfaillie, C.M. PLoS Biol. (2005) [Pubmed]
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