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Clic1  -  chloride intracellular channel 1

Mus musculus

Synonyms: Chloride intracellular channel protein 1, Clcp, G6, NCC27, Nuclear chloride ion channel 27
 
 
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High impact information on Clic1

  • Two novel macromolecular MRI contrast agents based upon generation-6 polyamidoamine dendrimers (G6) of presumed similar molecular size, but of different molecular weight, were compared in terms of their blood retention, tissue distribution, and renal excretion [1].
  • MATERIALS AND METHODS: A macromolecular MR/NIR optical contrast agent was synthesized based on a approximately 191 gadolinium-labeled contrast agent using generation-6 polyamidoamine dendrimer (G6), which is also labeled with 2 Cy5.5, an NIR fluorophore [2].
  • The chloride intracellular channel protein CLIC5 is expressed at high levels in hair cell stereocilia and is essential for normal inner ear function [3].
  • Refined immunolocalization in rat and chicken vestibular hair cells showed that CLIC5 is limited to the basal region of the hair bundle, similar to the known location of radixin [3].
  • These results suggest that CLIC5 associates with radixin in hair cell stereocilia and may help form or stabilize connections between the plasma membrane and the filamentous actin core [3].
 

Anatomical context of Clic1

  • In wild-type mice, CLIC5-specific immunofluorescence was detected in stereocilia of both cochlear and vestibular hair cells and also along the apical surface of Kolliker's organ during cochlear development [3].
  • By mass spectrometry and immunoblotting, CLIC5 was shown to be expressed at high levels in stereocilia of the chicken utricle, in an approximate 1:1 molar ratio with radixin [3].
 

Analytical, diagnostic and therapeutic context of Clic1

References

  1. Comparison of the macromolecular MR contrast agents with ethylenediamine-core versus ammonia-core generation-6 polyamidoamine dendrimer. Kobayashi, H., Sato, N., Kawamoto, S., Saga, T., Hiraga, A., Haque, T.L., Ishimori, T., Konishi, J., Togashi, K., Brechbiel, M.W. Bioconjug. Chem. (2001) [Pubmed]
  2. A dendrimer-based nanosized contrast agent dual-labeled for magnetic resonance and optical fluorescence imaging to localize the sentinel lymph node in mice. Koyama, Y., Talanov, V.S., Bernardo, M., Hama, Y., Regino, C.A., Brechbiel, M.W., Choyke, P.L., Kobayashi, H. Journal of magnetic resonance imaging : JMRI (2007) [Pubmed]
  3. The chloride intracellular channel protein CLIC5 is expressed at high levels in hair cell stereocilia and is essential for normal inner ear function. Gagnon, L.H., Longo-Guess, C.M., Berryman, M., Shin, J.B., Saylor, K.W., Yu, H., Gillespie, P.G., Johnson, K.R. J. Neurosci. (2006) [Pubmed]
 
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