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Gene Review:

y0989 - hypothetical protein

Yersinia pestis KIM10+

Bennett, A.M. et al., Simpson, W.J. et al.

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Disease relevance of y0989

Yersinia pestis produces a glycoprotein capsule, the biosynthesis of which appears to be temperature dependent [1].
Plasmids expressing the V antigen of Yersinia pestis or the E2 glycoprotein of Venezuelan Equine Encephalitis (VEE) virus were used to vaccinate mice by intra-dermal or intra-muscular injection, or by particle-mediated bombardment using the Helios gene gun [2].

References

Recombinant capsular antigen (fraction 1) from Yersinia pestis induces a protective antibody response in BALB/c mice. Simpson, W.J., Thomas, R.E., Schwan, T.G. Am. J. Trop. Med. Hyg. (1990) [Pubmed]
Gene gun mediated vaccination is superior to manual delivery for immunisation with DNA vaccines expressing protective antigens from Yersinia pestis or Venezuelan Equine Encephalitis virus. Bennett, A.M., Phillpotts, R.J., Perkins, S.D., Jacobs, S.C., Williamson, E.D. Vaccine (1999) [Pubmed]

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