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Gene Review

Gm4736  -  predicted gene 4736

Mus musculus

Synonyms: EG114600, Mp4, Mp6
 
 
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Disease relevance of EG114600

 

High impact information on EG114600

  • Importantly, the administration of MP4 completely suppressed the development of EAE initiated by the cotransfer of both MBP- and PLP-activated T cells [1].
  • Prevention of clinical disease after the intravenous injection of MP4 was paralleled by the formation of long-lived functional peptide-MHC complexes in vivo, as well as by a significant reduction in both MBP- and PLP-specific T cell proliferative responses [1].
  • Finally, MP4 therapy was equally efficacious in mice defective in Fas expression [1].
  • Treatment of SJL/J mice with MP4 after induction of EAE either by active immunization or by adoptive transfer of activated T cells completely prevented subsequent clinical paralysis [1].
  • The first element displays an enhancerlike activity and is coincident with the binding of a nuclear factor (designated MP4; position -1078 to -1052 in the long terminal repeat) whose presence is apparently restricted to mammary cell lines [3].
 

Biological context of EG114600

  • Nucleotide sequence analysis of the genome of EV71 strain MP4 revealed four nucleotide changes on the 5' untranslated region, three on the VP2 region, and eight on the 2C region, resulting in one and four amino acid substitutions in the VP2 and 2C proteins, respectively [2].
 

Associations of EG114600 with chemical compounds

  • MP5 was 80% identical to the sequence of MP4 and had a high degree of similarity (60%) at its 3'-untranslated region to rat salivary glutamate/glutamine-rich protein (GRP) cDNA [4].
  • RNA dot-blots probed with PRP-gene-specific oligonucleotides established that MP3, MP4 and MP5 PRP mRNA were all induced by isoprenaline [4].

References

  1. Treatment of experimental encephalomyelitis with a novel chimeric fusion protein of myelin basic protein and proteolipid protein. Elliott, E.A., McFarland, H.I., Nye, S.H., Cofiell, R., Wilson, T.M., Wilkins, J.A., Squinto, S.P., Matis, L.A., Mueller, J.P. J. Clin. Invest. (1996) [Pubmed]
  2. A mouse-adapted enterovirus 71 strain causes neurological disease in mice after oral infection. Wang, Y.F., Chou, C.T., Lei, H.Y., Liu, C.C., Wang, S.M., Yan, J.J., Su, I.J., Wang, J.R., Yeh, T.M., Chen, S.H., Yu, C.K. J. Virol. (2004) [Pubmed]
  3. Two regions of the mouse mammary tumor virus long terminal repeat regulate the activity of its promoter in mammary cell lines. Lefebvre, P., Berard, D.S., Cordingley, M.G., Hager, G.L. Mol. Cell. Biol. (1991) [Pubmed]
  4. cDNA clones for mouse parotid proline-rich proteins. mRNA regulation by isoprenaline and the nucleotide sequence of proline-rich protein cDNA MP5. Layfield, R., Bannister, A.J., Pierce, E.J., McDonald, C.J. Eur. J. Biochem. (1992) [Pubmed]
 
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