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Gene Review

Add1  -  adducin 1 (alpha)

Mus musculus

Synonyms: AI256389, Alpha-adducin, Erythrocyte adducin subunit alpha
 
 
 
 
 
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High impact information on Add1

  • Identification of the cytoskeletal regulatory protein alpha-adducin as a target of T cell receptor signaling [1].
  • However, while phorbol ester induced rapid phosphorylation of both the phospho-sensitive epitope and the functionally defined major protein kinase C site present near the carboxy-terminus (serine 724) of alpha-adducin, only the phospho-sensitive epitope was modified upon activation through the TCR [1].
 

Biological context of Add1

  • These results suggest a model in which reorganization of the unique cytoskeletal network that defines a primary quiescent T lymphocyte is mediated in part through the TCR-dependent modification and subsequent down-regulation of alpha-adducin, thereby resulting in a cytoskeletal architecture compatible with T cell effector and memory functions [1].

References

  1. Identification of the cytoskeletal regulatory protein alpha-adducin as a target of T cell receptor signaling. Lu, Q., Liu, X., Trama, J., Roti, M.A., Go, W.Y., Ho, S.N. Mol. Immunol. (2004) [Pubmed]
 
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