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Gene Review:

lef - lethal factor

Bacillus anthracis str. A2012

Xu, L. et al., Berg, T. et al.

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Disease relevance of lef

Lethal factor (LF), along with its receptor-binding partner protective antigen (PA), forms lethal toxin (LT), a critical virulence factor for Bacillus anthracis [1].

Analytical, diagnostic and therapeutic context of lef

Following microscopic examination, DNA was extracted from blood smears and subjected to a multiplex PCR assay targeting the Ba813, cap and lef markers [2].

References

Bacillus anthracis: A multi-faceted role for anthrax lethal toxin in thwarting host immune defenses. Xu, L., Frucht, D.M. Int. J. Biochem. Cell Biol. (2007) [Pubmed]
Comparison of PCR, culture and microscopy of blood smears for the diagnosis of anthrax in sheep and cattle. Berg, T., Suddes, H., Morrice, G., Hornitzky, M. Lett. Appl. Microbiol. (2006) [Pubmed]

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