Gene Review:
Map3k8 - mitogen-activated protein kinase kinase...
Rattus norvegicus
Synonyms:
D17TPL2, Mitogen-activated protein kinase kinase kinase 8, TPL-2, Tpl-2, Tpl2, ...
- Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation. Patriotis, C., Makris, A., Bear, S.E., Tsichlis, P.N. Proc. Natl. Acad. Sci. U.S.A. (1993)
- TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105. Belich, M.P., Salmerón, A., Johnston, L.H., Ley, S.C. Nature (1999)
- Structure of a Moloney murine leukemia virus-virus-like 30 recombinant: implications for transduction of the c-Ha-ras proto-oncogene. Makris, A., Patriotis, C., Bear, S.E., Tsichlis, P.N. J. Virol. (1993)
- Genomic organization and expression of Tpl-2 in normal cells and Moloney murine leukemia virus-induced rat T-cell lymphomas: activation by provirus insertion. Makris, A., Patriotis, C., Bear, S.E., Tsichlis, P.N. J. Virol. (1993)
- Tpl-2 induces apoptosis by promoting the assembly of protein complexes that contain caspase-9, the adapter protein Tvl-1, and procaspase-3. Patriotis, C., Russeva, M.G., Lin, J.H., Srinivasula, S.M., Markova, D.Z., Tsatsanis, C., Makris, A., Alnemri, E.S., Tsichlis, P.N. J. Cell. Physiol. (2001)
- Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart. Kim, S.O., Irwin, P., Katz, S., Pelech, S.L. J. Cell. Biochem. (1998)