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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Lgals8  -  lectin, galactoside-binding, soluble, 8

Rattus norvegicus

Synonyms: 30 kDa S-type lectin, Gal-8, Galectin-8, RL-30
 
 
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High impact information on Lgals8

  • From a panel of monoclonal antibodies raised against fractions of rat liver nuclear envelopes (NEs), we have identified an antibody, RL30, which reacts with novel nuclear pore complex (NPC) antigens that are not O-glycosylated [1].
  • By immunofluorescence staining of cultured cells, RL30 reacts exclusively with the NE in a punctate pattern that largely coincides with that of identified NPC proteins [1].
  • Together with galectin-4, galectin-8 therefore represents a subfamily of galectins consisting of a tandem repeat of structurally different carbohydrate recognition domains within a single polypeptide chain [2].
 

Analytical, diagnostic and therapeutic context of Lgals8

  • RL30 labels only the cytoplasmic surface of the NPC in immunogold electron microscopy, predominantly in peripheral regions nearby the cytoplasmic ring [1].

References

  1. Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex. Byrd, D.A., Sweet, D.J., Panté, N., Konstantinov, K.N., Guan, T., Saphire, A.C., Mitchell, P.J., Cooper, C.S., Aebi, U., Gerace, L. J. Cell Biol. (1994) [Pubmed]
  2. Galectin-8. A new rat lectin, related to galectin-4. Hadari, Y.R., Paz, K., Dekel, R., Mestrovic, T., Accili, D., Zick, Y. J. Biol. Chem. (1995) [Pubmed]
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