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Gene Review:

Bin1 - bridging integrator 1

Rattus norvegicus

Synonyms: Amph2, Amphiphysin II, Amphiphysin-like protein, Amphl, Bridging integrator 1, ...

Owen, D.J. et al., Hosoya, O. et al., Szaszák, M. et al., Wigge, P. et al., Koo, Y.J. et al.

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Psychiatry related information on Bin1

Electroconvulsive shock increases the phosphorylation of amphiphysin II in the rat cerebellum [1].

High impact information on Bin1

Conversely, replacing the n-Src loop of the N-terminal SH3 domain of Grb2 with that of Amph2 causes it to favour dynamin ring disassembly [2].
Transferrin uptake assays show that shortening the n-Src loop of Amph2 SH3 reduces the ability of this domain to inhibit endocytosis in vivo [2].
Green fluorescent protein-tagged Src homology 3 (SH3) domains of endophilin I and amphiphysin II, two major binding partners of dynamins, also inhibited AT1A receptor-mediated endocytosis of angiotensin II [3].
Like Amph1, a role in endocytosis at the nerve terminal is supported by the rapid dephosphorylation of Amph2 on depolarization [4].
Amphiphysin I is a nerve terminal-enriched protein, and involved in synaptic vesicle endocytosis as heterodimer with amphiphysin II, an isoform of amphiphysin I [5].

Biological context of Bin1

Deletion of a unique insert in the n-Src loop of Amph2 SH3, a loop adjacent to the dynamin binding site, significantly reduces this effect [2].

Analytical, diagnostic and therapeutic context of Bin1

By immunoprecipitation and double-immunolabelling, amphiphysin Ir was shown to be associated not only with amphiphysin II, but also with dynamin, clathrin and alpha-adaptin that are involved in synaptic vesicle recycling [5].

References

Electroconvulsive shock increases the phosphorylation of amphiphysin II in the rat cerebellum. Koo, Y.J., Kim, S.J., Jeon, S.H., Kim, S.R., Kang, U.G., Park, J.B., Kim, Y.S. Neurosci. Lett. (2002) [Pubmed]
Crystal structure of the amphiphysin-2 SH3 domain and its role in the prevention of dynamin ring formation. Owen, D.J., Wigge, P., Vallis, Y., Moore, J.D., Evans, P.R., McMahon, H.T. EMBO J. (1998) [Pubmed]
Role of the proline-rich domain of dynamin-2 and its interactions with Src homology 3 domains during endocytosis of the AT1 angiotensin receptor. Szaszák, M., Gáborik, Z., Turu, G., McPherson, P.S., Clark, A.J., Catt, K.J., Hunyady, L. J. Biol. Chem. (2002) [Pubmed]
Amphiphysin heterodimers: potential role in clathrin-mediated endocytosis. Wigge, P., Köhler, K., Vallis, Y., Doyle, C.A., Owen, D., Hunt, S.P., McMahon, H.T. Mol. Biol. Cell (1997) [Pubmed]
Localized expression of amphiphysin Ir, a retina-specific variant of amphiphysin I, in the ribbon synapse and its functional implication. Hosoya, O., Tsutsui, K., Tsutsui, K. Eur. J. Neurosci. (2004) [Pubmed]

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