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Gene Review

P2ry6  -  pyrimidinergic receptor P2Y, G-protein...

Rattus norvegicus

Synonyms: P2Y purinoceptor 6, P2Y6
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Disease relevance of P2ry6

  • After stab wound injury the additional expression of the P2Y2 and P2Y6 receptors, and an up-regulation of the P2Y1,4 receptor-labeling on astrocytic cell bodies and/or processes was observed [1].

High impact information on P2ry6

  • This notion is supported by molecular evidence that demonstrates the presence of P2Y6 receptor transcripts in rat pulmonary arterial smooth muscle [2].
  • Our findings demonstrate the presence of functional P2Y6 receptors in osteoclasts [3].
  • In contrast, UDP or INS48823 (P2Y6 agonists) induced a significant increase in the number of cells exhibiting NF-kappaB activation, a process sensitive to the proteasome inhibitor lactacystin [3].
  • P2Y receptor expression (P2Y2 and P2Y6) was detected in cultured MC and isolated glomeruli, and demonstrated a transient marked increase during anti-Thy1 disease [4].
  • Northern blots revealed an age-related increase in levels of mRNA for P2Y6 receptors in cultures obtained at postnatal days 1 and 5, respectively, but no change in transcripts for P2Y1 and P2Y2 [5].

Biological context of P2ry6


Associations of P2ry6 with chemical compounds

  • These results indicate that P2Y6 receptors mediate UTP-evoked noradrenaline release from rat sympathetic neurons via activation of protein kinase C, but not inhibition of K(M) channels [5].
  • 3. Uridine nucleotides also inhibited I(K(M)) in P2Y6 cRNA-injected cells (by up to 71% at 10 microM UTP; perforated-patch) [7].
  • 1. The P2Y6 receptor is a uridine nucleotide-specific G protein-linked receptor previously reported to stimulate the phosphoinositide (PI) pathway [7].

Other interactions of P2ry6

  • The wide distribution of the uridine nucleotide-activated P2Y2, P2Y4 and P2Y6 receptors suggests a role for UTP as an important extracellular signalling molecule [8].


  1. P2Y receptor expression on astrocytes in the nucleus accumbens of rats. Franke, H., Krügel, U., Grosche, J., Heine, C., Härtig, W., Allgaier, C., Illes, P. Neuroscience (2004) [Pubmed]
  2. Functional evidence for a novel suramin-insensitive pyrimidine receptor in rat small pulmonary arteries. Hartley, S.A., Kato, K., Salter, K.J., Kozlowski, R.Z. Circ. Res. (1998) [Pubmed]
  3. P2Y6 nucleotide receptors activate NF-kappaB and increase survival of osteoclasts. Korcok, J., Raimundo, L.N., Du, X., Sims, S.M., Dixon, S.J. J. Biol. Chem. (2005) [Pubmed]
  4. P2 receptor antagonist PPADS inhibits mesangial cell proliferation in experimental mesangial proliferative glomerulonephritis. Rost, S., Daniel, C., Schulze-Lohoff, E., Bäumert, H.G., Lambrecht, G., Hugo, C. Kidney Int. (2002) [Pubmed]
  5. UTP evokes noradrenaline release from rat sympathetic neurons by activation of protein kinase C. Vartian, N., Moskvina, E., Scholze, T., Unterberger, U., Allgaier, C., Boehm, S. J. Neurochem. (2001) [Pubmed]
  6. P2 purinoceptor-mediated control of rat cerebral (pial) microvasculature; contribution of P2X and P2Y receptors. Lewis, C.J., Ennion, S.J., Evans, R.J. J. Physiol. (Lond.) (2000) [Pubmed]
  7. Dual coupling of heterologously-expressed rat P2Y6 nucleotide receptors to N-type Ca2+ and M-type K+ currents in rat sympathetic neurones. Filippov, A.K., Webb, T.E., Barnard, E.A., Brown, D.A. Br. J. Pharmacol. (1999) [Pubmed]
  8. Quantitation of extracellular UTP using a sensitive enzymatic assay. Lazarowski, E.R., Harden, T.K. Br. J. Pharmacol. (1999) [Pubmed]
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