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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Epn1  -  Epsin 1

Rattus norvegicus

Synonyms: EPS-15-interacting protein 1, Epsin-1
 
 
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High impact information on Epn1

  • Overexpression of a mutant, epsin Lys76 --> Ala76, with an ENTH domain defective in phosphoinositide binding, blocked epidermal growth factor internalization in COS-7 cells [1].
  • Endocytic proteins such as epsin, AP180, and Hip1R (Sla2p) share a conserved modular region termed the epsin NH2-terminal homology (ENTH) domain, which plays a crucial role in clathrin-mediated endocytosis through an unknown target [1].
  • By contrast, recruitment of GFP chimeras of clathrin, epsin, and amphiphysin was not observed [2].
  • The interaction of epsin and Eps15 with the clathrin adaptor AP-2 is inhibited by mitotic phosphorylation and enhanced by stimulation-dependent dephosphorylation in nerve terminals [3].
  • Dynamin I and at least five other nerve terminal proteins, amphiphysins I and II, synaptojanin, epsin and eps15 (collectively called dephosphins), are coordinately dephosphorylated by calcineurin during endocytosis of synaptic vesicles [4].
 

Biological context of Epn1

 

Other interactions of Epn1

  • The discrete interaction sequences within HIP1 that facilitate binding are analogous to motifs present in other accessory proteins, including AP180, amphiphysin, and epsin [6].

References

  1. Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis. Itoh, T., Koshiba, S., Kigawa, T., Kikuchi, A., Yokoyama, S., Takenawa, T. Science (2001) [Pubmed]
  2. Mechanisms of dense core vesicle recapture following "kiss and run" ("cavicapture") exocytosis in insulin-secreting cells. Tsuboi, T., McMahon, H.T., Rutter, G.A. J. Biol. Chem. (2004) [Pubmed]
  3. The interaction of epsin and Eps15 with the clathrin adaptor AP-2 is inhibited by mitotic phosphorylation and enhanced by stimulation-dependent dephosphorylation in nerve terminals. Chen, H., Slepnev, V.I., Di Fiore, P.P., De Camilli, P. J. Biol. Chem. (1999) [Pubmed]
  4. Protein phosphorylation is required for endocytosis in nerve terminals: potential role for the dephosphins dynamin I and synaptojanin, but not AP180 or amphiphysin. Cousin, M.A., Tan, T.C., Robinson, P.J. J. Neurochem. (2001) [Pubmed]
  5. Heterogeneity of endocytic proteins: distribution of clathrin adaptor proteins in neurons and glia. Yao, P.J., Zhang, P., Mattson, M.P., Furukawa, K. Neuroscience (2003) [Pubmed]
  6. Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins. Mishra, S.K., Agostinelli, N.R., Brett, T.J., Mizukami, I., Ross, T.S., Traub, L.M. J. Biol. Chem. (2001) [Pubmed]
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