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Nsmf  -  NMDA receptor synaptonuclear signaling and...

Rattus norvegicus

Synonyms: Jac, Jacob, Jacob protein, Juxtasynaptic attractor of caldendrin on dendritic boutons protein, Nasal embryonic LHRH factor, ...
 
 
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Disease relevance of Nelf

  • Previous studies (Stetler, D. A., and Jacob, S. T. (1984) J. Biol. Chem. 259, 7239-7244) have shown that poly(A) polymerase from adult rat liver (liver-type) is structurally and immunologically distinct from the corresponding rat hepatoma (tumor-type) enzyme [1].
  • The obese gene product leptin is an important signaling protein that regulates food intake and body weight via activation of the hypothalamic leptin receptor (Ob-Rb; Jacob et al., 1997) [2].
 

High impact information on Nelf

  • The acceleration of outgrowth is due to an acceleration of SCb, the rate [slow (SC)] component of axonal transport that carries cytomatrix proteins; this occurs throughout the axon by 7 days after the conditioning axotomy (Jacob and McQuarrie, 1991a, J. Neurobiol. 22:570-583) [3].
  • Because the rate of outgrowth correlated closely with the rate of SCb in outgrowing sprouts (McQuarrie and Jacob, J. Comp. Neurol. 305:139-147, 1991), we conclude that SCb is accelerated throughout the length of the axon by 7 days after axotomy [4].
  • Our laboratory has demonstrated (Steen MS, Foianini KR, Youngblood EB, Kinnick TR, Jacob S, and Henriksen EJ, J Appl Physiol 86: 2044-2051, 1999) that exercise training and treatment with the angiotensin-converting enzyme (ACE) inhibitor trandolapril interact to improve insulin action in insulin-resistant obese Zucker rats [5].
  • The initial genetic linkage map of the rat contained 432 genetic markers (Jacob et al. 1995) out of 1171 developed due to the relatively low polymorphism rate of the mapping cross used (SHR x BN) when compared to the interspecific crosses in the mouse [6].
  • Nutrition Classics. Journal of the American Chemical Society 59:1052-4, 1937. Synthesis of vitamin B1. By Joseph K. Cline, Robert R. Williams, and Jacob Finkeltstein [7].
 

Associations of Nelf with chemical compounds

  • These reports contrast with earlier reports [Smuckler, E. A. and Tata, J. R. (1971) Nat. New Biol. 234, 37--39; Sajdel, E. M. and Jacob, S. T. (1971) Biochem. Biophys. Res. Commun. 45, 707--715] [8].
  • The relative potency of the non-selective beta-blocker propranolol in inhibiting the agonist mediated relaxant activity was similar for all agonists examined, indicative of interactions at the same receptor site (Tallarida and Jacob 1979) [9].
 

Other interactions of Nelf

  • The protein kinase possessed reaction characteristics similar to those of the NII protein kinase (Rose, K.M., Bell, L.E., Siefken, D.A. and Jacob, S.T. (1981) J. Biol. Chem. 256, 7468-7477) which is associated with hepatoma RNA polymerase I (Rose, K.M., Stetler, D.A. and Jacob, S.T. (1981) Proc. Natl. Acad. Sci. U.S.A. 78, 2833-2837) [10].
 

Analytical, diagnostic and therapeutic context of Nelf

  • Previous studies had shown that the rate of the most rapid subcomponent of actin and tubulin transport (called SCb) accelerates following axotomy (J. Jacob and I. McQuarrie, J. Neurobiol. 22: 570-583, 1991) [11].

References

  1. Association of poly(A) polymerase with U1 RNA. Raju, V.S., Jacob, S.T. J. Biol. Chem. (1988) [Pubmed]
  2. Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity. Shanley, L.J., Irving, A.J., Harvey, J. J. Neurosci. (2001) [Pubmed]
  3. Acceleration of axonal outgrowth in rat sciatic nerve at one week after axotomy. Jacob, J.M., McQuarrie, I.G. J. Neurobiol. (1993) [Pubmed]
  4. Axotomy accelerates slow component b of axonal transport. Jacob, J.M., McQuarrie, I.G. J. Neurobiol. (1991) [Pubmed]
  5. Effects of exercise training and ACE inhibition on insulin action in rat skeletal muscle. Foianini, K.R., Steen, M.S., Kinnick, T.R., Schmit, M.B., Youngblood, E.B., Henriksen, E.J. J. Appl. Physiol. (2000) [Pubmed]
  6. An integrated genetic linkage map of the laboratory rat. Brown, D.M., Matise, T.C., Koike, G., Simon, J.S., Winer, E.S., Zangen, S., McLaughlin, M.G., Shiozawa, M., Atkinson, O.S., Hudson, J.R., Chakravarti, A., Lander, E.S., Jacob, H.J. Mamm. Genome (1998) [Pubmed]
  7. Nutrition Classics. Journal of the American Chemical Society 59:1052-4, 1937. Synthesis of vitamin B1. By Joseph K. Cline, Robert R. Williams, and Jacob Finkeltstein. Cline, J.K., Williams, R.R., Finkelstein, J. Nutr. Rev. (1977) [Pubmed]
  8. Variable stabilities and recoveries of rat-liver RNA polymerases A and B according to growth status of the tissue. Shields, D., Tata, J.R. Eur. J. Biochem. (1976) [Pubmed]
  9. Relationship between in vitro relaxation of the costo-uterine smooth muscle and mesovarial leiomyoma formation in vivo by beta-receptor agonists. Colbert, W.E., Wilson, B.F., Williams, P.D., Williams, G.D. Arch. Toxicol. (1991) [Pubmed]
  10. Protein kinase NII. Interaction with RNA polymerase II and contribution to immunological cross-reactivity of RNA polymerases I and II. Stetler, D.A., Rose, K.M. Biochim. Biophys. Acta (1983) [Pubmed]
  11. Increased beta-actin and tubulin polymerization in regrowing axons: relationship to the conditioning lesion effect. Lund, L.M., Machado, V.M., McQuarrie, I.G. Exp. Neurol. (2002) [Pubmed]
 
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