Disease relevance of Apod

• Molecular cloning of the mouse apolipoprotein D gene and its upregulated expression in Niemann-Pick disease type C mouse model [1].

High impact information on Apod

• In contrast, the level of ScRG-2, apolipoprotein D, and metallothionein II mRNA was only increased at the terminal stage of the disease [2].
• These include apolipoprotein D (apoD), the mouse homolog of oxysterol-binding protein-like protein 8 (OSBPL8), a diacylglycerol receptor (n-chimerin), and lysophosphatidic acid (LPA) acyltransferase [3].
• Using an automated genomics approach, total gene expression analysis (TOGA), we found an approximately threefold increase in the accumulation of the mRNA encoding apolipoprotein D (apoD) in mouse striatum in response to chronic treatment with clozapine [4].
• Clozapine specifically alters the arachidonic acid pathway in mice lacking apolipoprotein D [5].
• Our results suggest that the amniote last common ancestor expressed ApoD and PGDS in the brain during embryogenesis [6].

Biological context of Apod

• Localization of the gene for apolipoprotein D on mouse chromosome 16 [7].
• Moreover, many lipocalins have been implicated in the regulation of cell homeostasis: apolipoprotein D, quiescience specific protein, purpurin, alpha-1-microglobulin, and NGAL [8].
• Molecular characterization and differential mRNA tissue distribution of mouse apolipoprotein D [9].
• The mouse apolipoprotein D gene was isolated from a brain cDNA library [9].
• Here we report the structure of the mouse ApoD gene, which is composed of six exons spanning approximately 20 kb in length [1].

Anatomical context of Apod

• Investigation of cell lines exhibiting characteristics of hair and supporting cells revealed no Apod mRNA expression in these cells [10].
• The ApoD cDNA coding for murine apolipoprotein D (ApoD) was cloned from a mammary gland library and sequenced [11].
• Expression of the carrier protein apolipoprotein D in the mouse inner ear [10].
• Northern blot analysis revealed that ApoD was highly expressed in the brain and adipose tissue in mouse [1].
• In situ hybridization for the brain showed that ApoD mRNA was mainly localized in the subarachnoid space including the pia [1].

Associations of Apod with chemical compounds

• The primary structure and diverse expression of ApoD suggest that this protein is a multiligand, multifunctional glycoprotein [1].

Other interactions of Apod

• Interestingly, unlike in other species, ApoD RNA is not found in spleen, liver, pancreas or kidney [11].
• Apolipoprotein D in the Niemann-Pick type C disease mouse brain: an ultrastructural immunocytochemical analysis [12].
• Modulation of apolipoprotein D and apolipoprotein E expression in rat hippocampus after entorhinal cortex lesion [13].

Analytical, diagnostic and therapeutic context of Apod

• The cochlear enriched expression of Apod was validated by quantitative real time PCR analysis [10].
• Clozapine increases apolipoprotein D expression in rodent brain: towards a mechanism for neuroleptic pharmacotherapy [4].

References