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Gene Review

Gjc3  -  gap junction protein, gamma 3

Mus musculus

Synonyms: Connexin-29, Cx29, Gap junction epsilon-1 protein, Gap junction gamma-3 protein, Gje1, ...
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Disease relevance of Gje1

  • In contrast, decreases in MAG expression and severe demyelination at the soma of SG neurons were found in Cx29(-/-) mice [1].

High impact information on Gje1

  • The R142W mutant protein was aberrantly localized to the Golgi, indicating that it does not traffic properly, but the molecular organization of the myelin sheath, including the localization of Cx29, another connexin expressed by myelinating Schwann cells, was not disrupted [2].
  • In mature myelin-forming Schwann cells, expression of multiple connexins, i.e. connexin (Cx) 43, Cx29, Cx32, and Cx46 (after nerve injury) has been detected [3].
  • The only exception to this were dorsal roots, where the expression of Cx29 was delayed four days relative to ventral roots and spinal nerves [3].
  • This identifies Cx29 as a novel marker for cells of the defined Schwann cell lineage [3].
  • Cx29 protein expression was absent from neural crest cells but appeared as neural crest cells generated precursors (embryonic day 12) both in vivo and in vitro [3].

Biological context of Gje1


Anatomical context of Gje1


Regulatory relationships of Gje1

  • Cx29 expressed in N2A cells did not induce intercellular conductances but did participate in the formation of active channels when coexpressed with Cx32 [10].

Other interactions of Gje1


Analytical, diagnostic and therapeutic context of Gje1


  1. Connexin29 is highly expressed in cochlear Schwann cells, and it is required for the normal development and function of the auditory nerve of mice. Tang, W., Zhang, Y., Chang, Q., Ahmad, S., Dahlke, I., Yi, H., Chen, P., Paul, D.L., Lin, X. J. Neurosci. (2006) [Pubmed]
  2. The effects of a dominant connexin32 mutant in myelinating Schwann cells. Jeng, L.J., Balice-Gordon, R.J., Messing, A., Fischbeck, K.H., Scherer, S.S. Mol. Cell. Neurosci. (2006) [Pubmed]
  3. Analysis of connexin expression during mouse Schwann cell development identifies connexin29 as a novel marker for the transition of neural crest to precursor cells. Li, J., Habbes, H.W., Eiberger, J., Willecke, K., Dermietzel, R., Meier, C. Glia (2007) [Pubmed]
  4. Expression patterns of connexin 29 (GJE1) in mouse and rat cochlea. Yang, J.J., Liao, P.J., Su, C.C., Li, S.Y. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  5. Expression pattern and functional characterization of connexin29 in transgenic mice. Eiberger, J., Kibschull, M., Strenzke, N., Schober, A., Büssow, H., Wessig, C., Djahed, S., Reucher, H., Koch, D.A., Lautermann, J., Moser, T., Winterhager, E., Willecke, K. Glia (2006) [Pubmed]
  6. Cloning, embryonic expression, and functional characterization of two novel connexins from Xenopus laevis. de Boer, T.P., Kok, B., Roël, G., van Veen, T.A., Destrée, O.H., Rook, M.B., Vos, M.A., de Bakker, J.M., van der Heyden, M.A. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  7. Unique distributions of the gap junction proteins connexin29, connexin32, and connexin47 in oligodendrocytes. Kleopa, K.A., Orthmann, J.L., Enriquez, A., Paul, D.L., Scherer, S.S. Glia (2004) [Pubmed]
  8. Connexin29 and connexin32 at oligodendrocyte and astrocyte gap junctions and in myelin of the mouse central nervous system. Nagy, J.I., Ionescu, A.V., Lynn, B.D., Rash, J.E. J. Comp. Neurol. (2003) [Pubmed]
  9. Connexin29 expression, immunocytochemistry and freeze-fracture replica immunogold labelling (FRIL) in sciatic nerve. Li, X., Lynn, B.D., Olson, C., Meier, C., Davidson, K.G., Yasumura, T., Rash, J.E., Nagy, J.I. Eur. J. Neurosci. (2002) [Pubmed]
  10. Connexin29 is uniquely distributed within myelinating glial cells of the central and peripheral nervous systems. Altevogt, B.M., Kleopa, K.A., Postma, F.R., Scherer, S.S., Paul, D.L. J. Neurosci. (2002) [Pubmed]
  11. Connexin47, connexin29 and connexin32 co-expression in oligodendrocytes and Cx47 association with zonula occludens-1 (ZO-1) in mouse brain. Li, X., Ionescu, A.V., Lynn, B.D., Lu, S., Kamasawa, N., Morita, M., Davidson, K.G., Yasumura, T., Rash, J.E., Nagy, J.I. Neuroscience (2004) [Pubmed]
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