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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Arl4a  -  ADP-ribosylation factor-like 4A

Mus musculus

Synonyms: ADP-ribosylation factor-like protein 4A, AI467555, Arl4
 
 
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High impact information on Arl4a

  • It is suggested that the disruption of Arl4 produces a moderate retardation of germ cell development, possibly at the stage of meiosis [1].
  • However, inactivation of the Arl4 gene resulted in a significant reduction of testis weight and sperm count by 30 and 60%, respectively, without reduction of litter size or frequency [1].
  • We further demonstrate that 1 of these genes, Troy, is a direct target of canonical WNT signaling, while the other 2 genes, Selp and Arl4, are not [2].
  • In contrast, the upstream promoter seems to drive specifically the expression of Arl4 in adult testis [3].
  • Both 5'-flanking regions exhibited promoter activity when expressed in COS-7 cells, indicating that the expression of Arl4 is directed by two separate promoters. mRNA transcribed under the control of the downstream promoter was isolated by RACE-PCR from all investigated tissues [3].
 

Analytical, diagnostic and therapeutic context of Arl4a

  • Reduced sperm count and normal fertility in male mice with targeted disruption of the ADP-ribosylation factor-like 4 (Arl4) gene [1].

References

  1. Reduced sperm count and normal fertility in male mice with targeted disruption of the ADP-ribosylation factor-like 4 (Arl4) gene. Schürmann, A., Koling, S., Jacobs, S., Saftig, P., Krauss, S., Wennemuth, G., Kluge, R., Joost, H.G. Mol. Cell. Biol. (2002) [Pubmed]
  2. Microarray analysis of somitogenesis reveals novel targets of different WNT signaling pathways in the somitic mesoderm. Buttitta, L., Tanaka, T.S., Chen, A.E., Ko, M.S., Fan, C.M. Dev. Biol. (2003) [Pubmed]
  3. The mouse ADP-ribosylation factor-like 4 gene: two separate promoters direct specific transcription in tissues and testicular germ cell. Jacobs, S., Schürmann, A., Becker, W., Böckers, T.M., Copeland, N.G., Jenkins, N.A., Joost, H.G. Biochem. J. (1998) [Pubmed]
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