Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

lysS - lysine--tRNA ligase

Borrelia burgdorferi B31

Mejlhede, N. et al., Jester, B.C. et al.

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Disease relevance of BB0659

To investigate the utility of the class I LysRS as a diagnostic target for Lyme disease, the corresponding gene ( lysK) was cloned and sequenced from B. afzelii, B. garinii, and B. hermsii [1].
Differentiation of Borrelia burgdorferi sensu lato strains using class I lysyl-tRNA synthetase-encoding genes [1].

High impact information on BB0659

Insertion of lysine during protein synthesis depends on the enzyme lysyl-tRNA synthetase (LysRS), which exists in two unrelated forms, LysRS1 and LysRS2 [2].
Nonorthologous replacement of lysyl-tRNA synthetase prevents addition of lysine analogues to the genetic code [2].

Biological context of BB0659

Comparative genome sequence analysis revealed that Borrelia burgdorferi sensu lato, the etiological agent of Lyme disease, contains a class I-type LysRS, whereas its tick and mammalian hosts would be expected to contain a class II-type protein [1].

References

Differentiation of Borrelia burgdorferi sensu lato strains using class I lysyl-tRNA synthetase-encoding genes. Mejlhede, N., Monthán, A., Theisen, M., Ibba, M. Med. Microbiol. Immunol. (Berl.) (2003) [Pubmed]
Nonorthologous replacement of lysyl-tRNA synthetase prevents addition of lysine analogues to the genetic code. Jester, B.C., Levengood, J.D., Roy, H., Ibba, M., Devine, K.M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]

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