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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

parC  -  DNA topoisomerase IV subunit A

Enterococcus faecalis V583

 
 
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Disease relevance of parC

  • The gyrA and parC genes of 31 clinical isolates of Enterococcus faecalis, including fluoroquinolone-resistant isolates, were partially sequenced and analyzed for target alterations [1].
 

High impact information on parC

 

Other interactions of parC

  • The quinolone resistance determining regions (QRDRs) of gyrA and parC in less-susceptible mutants were amplified by PCR and sequenced [3].

References

  1. Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis. Kanematsu, E., Deguchi, T., Yasuda, M., Kawamura, T., Nishino, Y., Kawada, Y. Antimicrob. Agents Chemother. (1998) [Pubmed]
  2. In vitro activities of garenoxacin (BMS-284756) against Streptococcus pneumoniae, viridans group streptococci, and Enterococcus faecalis compared to those of six other quinolones. Grohs, P., Houssaye, S., Aubert, A., Gutmann, L., Varon, E. Antimicrob. Agents Chemother. (2003) [Pubmed]
  3. In vitro development of resistance to DX-619 and other quinolones in enterococci. Wickman, P.A., Black, J.A., Smith Moland, E., Thomson, K.S., Hanson, N.D. J. Antimicrob. Chemother. (2006) [Pubmed]
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